Biblioteca Hospital 12 de Octubre

Quality of life in patients with non-muscle-invasive bladder cancer: one-year results of a multicentre prospective cohort study. (Registro nro. 17290)

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Campo de control de longitud fija nab a22 7a 4500
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Campo de control PC17290
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Campo de control 20230310115501.0
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9 (RLIN) 1783
Nombre de persona Cruz Bértolo, Javier de la
Término indicativo de función Epidemiología Clínica
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Título Quality of life in patients with non-muscle-invasive bladder cancer: one-year results of a multicentre prospective cohort study.
Tipo de material [artículo]
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Nombre del editor distribuidor etc. Urologic oncology,
Fecha de publicación distribución etc. 2015
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Extensión 33(1):19.e7-19.e15.
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Nota general Formato Vancouver:
Schmidt S, Francés A, Lorente Garín JA, Juanpere N, Lloreta Trull J, Bonfill X et al. Quality of life in patients with non-muscle-invasive bladder cancer: one-year results of a multicentre prospective cohort study. Urol Oncol. 2015 Jan;33(1):19.e7-19.e15.
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Nota de "Con" PMID: 25443270
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Nota de bibliografía etc. Contiene 30 referencias
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Sumario etc. Objective: Few studies describe the effect of non-muscle-invasive bladder cancer (NMIBC) on health-related quality of life (HRQL), although patients are mostly diagnosed at this stage of the disease. Taking into account this current evidence gap and the high incidence rates in Spain, we aimed to describe the evolution over time of HRQL in Spanish patients with NMIBC and to examine the clinical and treatment-related factors associated with HRQL change during the first year of management.
Methods and materials: Observational multicenter prospective inception cohort study conducted in urology departments of 7 Spanish hospitals. A consecutive sample of 244 patients with anatomopathologically confirmed NMIBC, recruited from October 2010 to September 2011, was followed during the diagnostic process, and 6 and 12 months later. HRQL was assessed by generic and disease-specific instruments: the Short Form-36 (covering physical and mental health) and the Bladder Cancer Index, measuring urinary, bowel, and sexual domains (summary scores: 0-100). Bivariate analysis was performed and generalized estimating equation models were constructed to assess HRQL score change.
Results: Almost 52% of the patients were diagnosed at stage I, and 84% were men. The number of patients treated only with transurethral resection (TUR) was 144, and 82 also received intravesical therapy with bacillus Calmette-Guérin (BCG) or mitomycin C. Mental health was significantly worse than Short Form-36 reference norms at diagnosis (mean of 49.7 vs. 53.3, 95% CI: 52.5-54.2). Urinary domain improved significantly from diagnosis (85.2, 95% CI: 82.9-87.4) to 12-month evaluation (90.2, 95% CI: 87.7-92.8), whereas sexual domain showed deterioration from 56.4 (95% CI: 52.8-59.9) to 53.7 (95% CI: 50.0-57.4). Adjusted HRQL score changes from baseline to 12-month follow-up estimated with generalized estimating equation models showed improvement on the following parameters: urinary domain after TUR with or without intravesical therapy (+3.9, 95% CI: 0.1-7.7), bowel domain among patients treated with TUR and BCG (+7.0, 95% CI: 2.4-11.5), and sexual domain among those treated with TUR and mitomycin C (+13.1, 95% CI: 5.9-20.2).

Conclusions: For the first time, a distinctive HRQL pattern of bladder cancer treatment benefits emerges for TUR alone, and in combination with BCG or mitomycin C, which deserves further research. Treatment differences cannot be interpreted in terms of efficacy but can be useful to generate hypotheses to test in future studies.
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9 (RLIN) 625
Nombre de entidad o nombre de jurisdicción como elemento inicial Instituto de Investigación imas12
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Identificador Uniforme del Recurso (URI) http://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17290.pdf
Acceso Solicitar documento
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          Hospital Universitario 12 de Octubre Hospital Universitario 12 de Octubre 2023-03-10 PC17290 2023-03-10 2023-03-10 Artículo

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