Gastroenteropancreatic neuroendocrine tumor cancer stem cells: do they exist?. [artículo]
Por: Castellano, Daniel [Oncología Médica].
Colaborador(es): Servicio de Oncología Médica.
Editor: Cancer and Metastasis Reviews, 2012Descripción: 31(1-2):47-53.Recursos en línea: Solicitar documento Resumen: Neuroendocrine tumors (NETs) comprise a broad range of neoplasms that share biological and embryological origin. A deeper knowledge in the underlying molecular biology that results in the development and spread of NETs has allowed the use of novel-targeted therapies against angiogenesis and intracellular pathways, key checkpoints that govern growth, and proliferation of these tumors. Unfortunately, the possibility of cure is still far for patients with advanced stages. Cancer stem cells (CSCs) are present in most solid tumors. Nevertheless, there is limited evidence for the presence of CSCs in NETs. In this review, we will discuss the embryonic origin and possible existence of a gastroenteropancreatic neuroendocrine cancer stem cell. Here, we summarize the body of evidence supporting the presence of active embryological pathways like Notch, Wnt-beta-catenin, Hedgehog, or transforming growth factor-beta in NETs. New therapeutic approaches in the field of CSCs seem to have a clear role in the treatment of medulloblastomas and basal cell carcinomas, but their future value in other solid tumor types including NETs remains unclear.Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
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Artículo | PC5448 (Navegar estantería) | Disponible |
Formato Vancouver:
Grande E, Capdevila J, Barriuso J, Antón-Aparicio L, Castellano D.
Gastroenteropancreatic neuroendocrine tumor cancer stem cells: do they exist?. Cancer Metastasis Rev. 2012 Jun;31(1-2):47-53.
PMID: 22105614
Contiene 63 referencias
Neuroendocrine tumors (NETs) comprise a broad range of neoplasms that share biological and embryological origin. A deeper knowledge in the underlying molecular biology that results in the development and spread of NETs has allowed the use of novel-targeted therapies against angiogenesis and intracellular pathways, key checkpoints that govern growth, and proliferation of these tumors. Unfortunately, the possibility of cure is still far for patients with advanced stages. Cancer stem cells (CSCs) are present in most solid tumors. Nevertheless, there is limited evidence for the presence of CSCs in NETs. In this review, we will discuss the embryonic origin and possible existence of a gastroenteropancreatic neuroendocrine cancer stem cell. Here, we summarize the body of evidence supporting the presence of active embryological pathways like Notch, Wnt-beta-catenin, Hedgehog, or transforming growth factor-beta in NETs. New therapeutic approaches in the field of CSCs seem to have a clear role in the treatment of medulloblastomas and basal cell carcinomas, but their future value in other solid tumor types including NETs remains unclear.
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