El espectro bipolar [libro]
Por: Palomo Álvarez, Tomás , editor [Psiquiatría] | Jiménez Arriero, Miguel Ángel , editor [Psiquiatría].
Colaborador(es): Servicio de Psiquiatría.
Editor: Madrid : Editorial CYM, 2002Descripción: 344 p. ; 24 cm. Tipo de medio: JOUR Recursos en línea: Acceso Portada Resumen: Insulin-like growth factor I (IGF-I), a neuroprotective factor with a wide spectrum of actions in the adult brain is involved in the pathogenesis of Alzheimer's disease (AD). Circulating levels of IGF-I change in AD patients and are implicated in the clearance of brain amyloid beta (Lambda beta) complexes. To investigate this hypothesis, we screened the IGF-I gene for various well known single nucleotide polymorphisms (SNPs) covering % of the gene variability in a population of 2352 individuals. Genetic analysis indicated different distribution of genotypes of 1 single nucleotide polymorphism., and 1 extended haplotype in the AD population compared with healthy control subjects. In particular, the frequency of rs972936 GC, genotype was significantly greater in AD patients than in control subjects (63% vs. 55%). The rs972936 GG genotype was associated with an increased risk for disease, independently of apolipoprotein E genotype, and with enhanced circulating levels of IGF-I. These findings suggest that polymorphisms within the IGF-I gene could infer greater risk for AD through their effect on ICE-I levels, and confirm the physiological role IGF-I in the pathogenesis of AD. (C) 2011 IBRO All rights reserved.Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
---|---|---|---|---|
Libro | WM 207 ESP 2002 (Navegar estantería) | Disponible |
Navegando Hospital Universitario 12 de Octubre Estantes Cerrar el navegador de estanterías
WM 170 STR 1994 Strategies for studying brain disorders: Volume 1. Depressive, anxiety and drug abuse disorders | WM 204 TRA 2001 Trastornos cognitivos | WM 205 CUB 2005 El grupo paranoide | WM 207 ESP 2002 El espectro bipolar | WM 207 TRA 1999 Trastornos afectivos | WM 220 AGU 1998 Demencia: una aproximación práctica | WM220 BER 1992 Demencias: conceptos actuales |
Formato Vancouver:
Palomo T, Beninger RJ, Jiménez Arriero MA, Huertas E. El espectro bipolar. Madrid: Editorial CYM; 2002.
Insulin-like growth factor I (IGF-I), a neuroprotective factor with a wide spectrum of actions in the adult brain is involved in the pathogenesis of Alzheimer's disease (AD). Circulating levels of IGF-I change in AD patients and are implicated in the clearance of brain amyloid beta (Lambda beta) complexes. To investigate this hypothesis, we screened the IGF-I gene for various well known single nucleotide polymorphisms (SNPs) covering % of the gene variability in a population of 2352 individuals. Genetic analysis indicated different distribution of genotypes of 1 single nucleotide polymorphism., and 1 extended haplotype in the AD population compared with healthy control subjects. In particular, the frequency of rs972936 GC, genotype was significantly greater in AD patients than in control subjects (63% vs. 55%). The rs972936 GG genotype was associated with an increased risk for disease, independently of apolipoprotein E genotype, and with enhanced circulating levels of IGF-I. These findings suggest that polymorphisms within the IGF-I gene could infer greater risk for AD through their effect on ICE-I levels, and confirm the physiological role IGF-I in the pathogenesis of AD. (C) 2011 IBRO All rights reserved.
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