000			02968na a2200805 4500
999			_c10431 _d10431
003			PC10431
005			20180704125319.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aMartín Ramos, María Luisa _91463 _eGenética
245	0	0	_aApplication of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: Does-7/7q-detection by FISH have prognostic value?. _h[artículo]
260			_bLeukemia Research, _c2013
300			_a37(4):416-21.
500			_aFormato Vancouver: Ademà V, Hernández JM, Abáigar M, Lumbreras E, Such E, Calull A et al. Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: does -7/7q- detection by FISH have prognostic value? Leuk Res. 2013 Apr;37(4):416-21.
501			_aPMID: 23337401
504			_aContiene 23 referencias
520			_aChromosomal abnormalities are detected in 40-60% of patients with de novo myelodysplastic syndromes (MDS). This study used the FISH technique in 773 patients with de novo MDS without evidence of monosomy 7 (-7) or 7q deletion (7q-) by conventional G-banding cytogenetics (CC) to analyze their prognostic impact by FISH alone. FISH detected -7/7q- in 5.2% of patients. Presence of -7/7q- was associated with shorter overall survival than absence of such aberrations. Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC.
710			_91466 _aServicio de Genética
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc10431.pdf _ySolicitar documento
942			_n0 _2ddc _cART