000			nab a22 7a 4500
999			_c16024 _d16024
003			PC16024
005			20210318104738.0
008			200703b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91486 _aSegura de la Morena, Julián _eNefrología
100			_9539 _aRuilope Urioste, Luis Miguel _eNefrología
245	0	0	_aDiuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics. _h[artículo]
260			_bExpert opinion on pharmacotherapy, _c2014
300			_a15(4):527-47.
500			_aFormato Vancouver: Tamargo J, Segura J, Ruilope LM. Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics. Expert Opin Pharmacother. 2014 Mar;15(4):527-47.
501			_aPMID: 24444254
504			_aContiene 174 referencias
520			_aIntroduction: Thiazides and thiazide-like diuretics inhibit the electroneutral Na(+)-Cl(-) cotransporter located on the apical membrane of the early segment of the distal convoluted tubule. They have been widely prescribed over 60 years in the treatment of hypertension and various edematous states. Areas covered: Thiazide diuretics reduce blood pressure (BP), although the mechanisms by which they chronically lower BP remain unknown. These drugs present a flat dose-response curve that explains why when prescribed at high doses their use was associated with a wide range of adverse effects, particularly electrolyte changes and metabolic abnormalities that can be minimized at the low doses actually prescribed. This article reviews the clinical pharmacology of thiazide diuretics to provide an insight into the mechanisms involved in their antihypertensive and adverse effects, the determinants of drug response and the possible differences in their pharmacodynamic and pharmacokinetic properties in an attempt to improve their clinical use in the treatment of arterial hypertension. Expert opinion: At low doses, thiazide diuretics remain as an effective and safe therapeutic alternative in the treatment of hypertension. Additionally, their ability to increase the efficacy of nearly all other classes of antihypertensives makes them a highly versatile therapeutic intervention in the treatment of hypertension.
710			_986 _aServicio de Nefrología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16024.pdf _ySolicitar documento
942			_2ddc _cART _n0