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008			200709b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92077 _aGonzález de la Aleja Tejera, Jesús _eNeurología
100			_92071 _aRomero Muñoz, Juan Pablo _eInstituto de Investigación i+12
100			_91764 _aSaiz Díaz, Rosa Ana _eNeurología
100			_9892 _aBenito León, Julián _eNeurología
245	0	0	_aEffects of alprazolam on cortical activity and tremors in patients with essential tremor. _h[articulo]
260			_bPloS one, _c2014
300			_a9(3):e93159.
500			_aFormato Vancouver: Ibáñez J, González de la Aleja J, Gallego JA, Romero JP, Saíz-Díaz RA, Benito-León J et al. Effects of alprazolam on cortical activity and tremors in patients with essential tremor. PLoS One. 2014 Mar 25;9(3):e93159.
501			_aPMID: 24667763 PMC3965529
504			_aContiene 54 referencias
520			_aBackground: Essential tremor (ET) is characterised by postural and action tremors with a frequency of 4-12 Hz. Previous studies suggest that the tremor activity originates in the cerebello-thalamocortical pathways. Alprazolam is a short-acting benzodiazepine that attenuates tremors in ET. The mechanisms that mediate the therapeutic action of alprazolam are unknown; however, in healthy subjects, benzodiazepines increase cortical beta activity. In this study, we investigated the effect of alprazolam both on beta and tremor-related cortical activity and on alterations in tremor presentation in ET patients. Therefore, we characterised the dynamics of tremor and cortical activity in ET patients after alprazolam intake. Methods: We recorded hand tremors and contralateral cortical activity in four recordings before and after a single dose of alprazolam. We then computed the changes in tremors, cortico-muscular coherence, and cortical activity at the tremor frequency and in the beta band. Results: Alprazolam significantly attenuated tremors (EMG: 76.2 ± 22.68%), decreased cortical activity in the tremor frequency range and increased cortical beta activity in all patients (P<0.05). At the same time, the cortico-muscular coherence at the tremor frequency became non-significant (P<0.05). We also found a significant correlation (r = 0.757, P<0.001) between the reduction in tremor severity and the increased ratio of cortical activity in the beta band to the activity observed in the tremor frequency range. Conclusions: This study provides the first quantitative analysis of tremor reduction following alprazolam intake. We observed that the tremor severity decreased in association with an increased ratio of beta to tremor-related cortical activity. We hypothesise that the increase in cortical beta activity may act as a blocking mechanism and may dampen the pathological oscillatory activity, which in turn attenuates the observed tremor.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965529/ _yAcceso libre
942			_2ddc _cART _n0