000			nab a22 7a 4500
999			_c16537 _d16537
003			PC16537
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008			210712b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91091 _aHidalgo Pascual, Manuel _eCirugía General y del Aparato Digestivo
245	0	0	_aPost-operative benefits of Tisseel(®)/Tissucol (®) for mesh fixation in patients undergoing Lichtenstein inguinal hernia repair: secondary results from the TIMELI trial. _h[artículo]
260			_bHernia : the journal of hernias and abdominal wall surgery, _c2014
300			_a18(5):751-60.
500			_aFormato Vancouver: Campanelli G, Pascual MH, Hoeferlin A, Rosenberg J, Champault G, Kingsnorth A et al. Post-operative benefits of Tisseel(®)/Tissucol (®) for mesh fixation in patients undergoing Lichtenstein inguinal hernia repair: secondary results from the TIMELI trial. Hernia. 2014 Oct;18(5):751-60.
501			_aPMID: 24889273 PMC4177565
504			_aContiene 18 referencias
520			_aPurpose: The Tisseel/Tissucol for mesh fixation in Lichtenstein hernia repair (TIMELI) study showed that mesh fixation with human fibrin sealant during inguinal hernia repair significantly reduced moderate-severe complications of pain 12 months post-operatively compared with sutures. Further analyses may assist surgeons by investigating predictors of post-surgical complications and identifying patients that may benefit from Tisseel/Tissucol intervention. Methods: Univariate and multivariate analyses identified risk factors for combined pain, numbness and groin discomfort (PND) visual analogue scale (VAS) score 12 months post-operatively. Variables tested were: fixation method, age, employment status, physical activity, nerve handling, PND VAS score at pre-operative visit and 1 week post-operatively. The effect of fixation technique on separate PND outcomes 12 months post-surgery was also assessed. Analyses included the intention-to-treat (ITT) population and a subpopulation with pre-operative PND VAS > 30 mm. Results: 316 patients were included in the ITT, with 130 patients in the subpopulation with pre-operative PND VAS > 30. Multivariate analysis identified mesh fixation with sutures, worsening pre-operative PND and worsening PND 1 week post-surgery as significant predictors of 12-month PND in the ITT population; mesh fixation with sutures was a significant predictor of 12-month PND in the pre-operative PND VAS > 30 subpopulation (p < 0.05). Mesh fixation with Tisseel/Tissucol resulted in significantly less numbness and a lower intensity of groin discomfort compared with sutures at 12 months; there was no difference in pain between the treatment groups. Conclusions: Pre-operative discomfort may be an important predictor of post-operative pain, numbness and discomfort. Tisseel/Tissucol may improve long-term morbidity over conventional sutures in these patients.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177565/ _yAcceso libre
942			_2ddc _cART _n0