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999			_c16563 _d16563
003			PC16563
005			20210730144017.0
008			210728b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92657 _aGaratachea, Nuria _eInstituto de Investigación i+12
100			_92658 _aSantos Lozano, Alejandro _eInstituto de Investigación i+12
100			_92429 _aLucía, Alejandro _eInstituto de Investigación i+12
245	0	0	_aPTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. _b _h[artículo]
260			_bRejuvenation research, _c2014
300			_a17(5):430-8.
500			_aFormato Vancouver: Garatachea N, Fuku N, He ZH, Tian Y, Arai Y, Abe Y et al. PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. Rejuvenation Res. 2014 Oct;17(5):430-8.
501			_aPMID: 24930376; PMCID: PMC4203112
504			_aContiene 48 referencias
520			_aFocal adhesion is critical for cell survival. The focal adhesion kinase (FAK, or PTK2) is an important component of the human interactome and thus is a potential longevity-related protein. Here we studied the association between two PTK2 gene single-nucleotide polymorphisms (SNPs) (rs7843014, rs7460) and exceptional longevity (EL). In addition to gaining insight into their functionality by determining luciferase gene reporter activity, we studied the genotype/allele frequency of these two SNPs among three different cohorts: (1) Spanish centenarians (n=175, 100-111 years, 144 women) and healthy controls (n=355, 20-50 years, 284 women); (2) Italian centenarians (n=79, 100-104 years, 40 women) and controls (n=316, 29-50 years, 156 women); and (3) Japanese centenarians (n=742, 100-116 years, 623 women) and healthy controls (n=499, 23-59 years, 356 women). Both SNPs had functional significance, with the A allele up-regulating luciferase activity compared to the other allele (rs7460 T allele and rs7843014 C allele, respectively). The A allele of both SNPs was negatively associated with EL in the Spanish cohort (rs7460, odds ratio [OR] adjusted by sex=0.40, 95% confidence intervals [CI] 0.3, 0.6, p<0.001); rs7843014, OR=0.37, 95% CI 0.3, 0.5, p<0.001). The OR of being a centenarian if having the rs7460-TT genotype was 6.68 (95% CI 4.1, 10.8, p<0.001). The rs7843014 CC genotype was also positively associated with EL (OR=7.58, 95% CI 4.6, 12.3, p<0.001]. No association was, however, found for the Italian or Japanese cohorts. Thus, two genotypes of the FAK gene, rs7460 TT and rs7843014 CC, are possibly associated with lower gene expression and might favor the likelihood of reaching EL in the Spanish population. Further research is needed to unveil the mechanisms by which FAK expression could perhaps influence the rate of aging.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203112/ _yAcceso libre
942			_2ddc _cART _n0