000			nab a22 7a 4500
999			_c16566 _d16566
003			PC16566
005			20210811102423.0
008			210802b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91223 _aOrtiz Romero, Pablo Luis _eDermatología Médico-Quirúrgica y Venereología
100			_91219 _aRodríguez Peralto, José Luis _eAnatomía Patológica
245	0	0	_aRAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway. _h[artículo]
260			_bCancer cell, _c2014
300			_a26(1):61-76.
500			_aFormato Vancouver: Alonso Curbelo D, Riveiro Falkenbach E, Pérez Guijarro E, Cifdaloz M, Karras P, Osterloh L et al. RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway. Cancer Cell. 2014 Jul 14;26(1):61-76.
501			_aPMID: 24981740
504			_aContiene 51 referencias
520			_aAlthough common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells, clinical specimens, and mouse models demonstrated that RAB7 is an early-induced melanoma driver whose levels can be tuned to favor tumor invasion, ultimately defining metastatic risk. Importantly, RAB7 levels and function were independent of MITF, the best-characterized melanocyte lineage-specific transcription factor. Instead, we describe the neuroectodermal master modulator SOX10 and the oncogene MYC as RAB7 regulators. These results reveal a unique wiring of the lysosomal pathway that melanomas exploit to foster tumor progression.
710			_9145 _aServicio de Dermatología Médico-Quirúrgica y Venereología
710			_9625 _aInstituto de Investigación imas12
710			_9330 _aServicio de Anatomía Patológica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16566.pdf _ySolicitar documento
942			_2ddc _cART _n0