000			nab a22 7a 4500
999			_c16599 _d16599
003			PC16599
005			20211007102007.0
008			211007b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92657 _aGaratachea, Nuria _eInstituto de Investigación i+12
245	0	0	_aSerum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. _h[artículo]
260			_bThe American journal of medicine, _c2014
300			_a127(9):888-90.
500			_aFormato Vancouver: Emanuele E, Minoretti P, Pareja Galeano H, Sanchis Gomar F, Garatachea N, Lucia A. Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. Am J Med. 2014 Sep;127(9):888-90.
501			_aPMID: 24813865
504			_aContiene 27 referencias
520			_aBackground: Skeletal muscles produce irisin. Growing controversy exists on the association between this myokine and chronic disease risk. On the basis of the potential protective effects that irisin could exert on both vascular function and skeletal muscle mass, we hypothesized that an elevated level of this molecule may contribute to successful aging. Methods: Serum irisin levels were measured using enzyme-linked immunosorbent assay in disease-free centenarians, young healthy controls, and patients with precocious acute myocardial infarction. Results: We found the highest levels of serum irisin in disease-free centenarians (35.3 ± 5.5 ng/mL) compared with young healthy controls (20.7 ± 6.3 ng/mL) and especially with young patients with acute myocardial infarction (15.1 ± 5.4 ng/mL). Conclusions: Our study demonstrates that healthy centenarians are characterized by increased serum irisin levels, whereas levels of this molecule were found to be significantly lower in young patients with myocardial infarction. Our findings may prompt further research into the role played by irisin not only in vascular disorders but also in life span modulation.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16599.pdf _ySolicitar documento
942			_2ddc _cART _n0