000			nab a22 7a 4500
999			_c16607 _d16607
003			PC16607
005			20211018120457.0
008			211015b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9726 _aRubio Valladolid, Gabriel _ePsiquiatría
245	0	0	_aSocial defeat in adolescent mice increases vulnerability to alcohol consumption. _h[artículo]
260			_bAddiction biology, _c2014
300			_a21(1):87-97.
500			_aFormato Vancouver: Rodríguez Arias M, Navarrete F, Blanco Gandia MC, Arenas MC, Bartoll Andrés A, Aguilar MA et al. Social defeat in adolescent mice increases vulnerability to alcohol consumption. Addict Biol. 2016 Jan;21(1):87-97.
501			_aPMID: 25219790
504			_aContiene 52 referencias
520			_aThis study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on the reinforcing and motivational actions of ethanol in adult OF1 mice. Social interaction, emotional and cognitive behavioral aspects were also analyzed, and real-time polymerase chain reaction (PCR) experiments were performed to study gene expression changes in the mesocorticolimbic and hypothalamus-hypophysis-adrenal (HHA) axis. Social defeat did not alter anxiety-like behavior in the elevated plus maze or cognitive performance in the passive avoidance and Hebb-Williams tests. A social interaction test revealed depression-like symptoms and social subordination behavior in defeated OF1 mice. Interestingly, social defeat in adolescence significantly increased the number of effective responses, ethanol consumption values and motivation to drink. Finally, real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase and corticotropin-releasing hormone in the ventral tegmental area and paraventricular nucleus, respectively. In contrast, mu-opioid receptor gene expression was decreased in the nucleus accumbens of socially defeated mice. In summary, these findings suggest that exposure to social defeat during adolescence increases vulnerability to the rewarding effects of ethanol without affecting emotional or cognitive performance. The gene expression alterations we have observed in the mesocorticolimbic and HHA axis systems of defeated mice could be related with their increased ethanol consumption. These results endorse future research into pharmacological strategies that modulate these systems for the treatment of social stress-related alcohol consumption problems.
710			_9150 _aServicio de Psiquiatría
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16607.pdf _ySolicitar documento
942			_2ddc _cART _n0