000			nab a22 7a 4500
999			_c16609 _d16609
003			PC16609
005			20211020110904.0
008			211018b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91162 _aUrruzono Tellería, Pedro _ePediatría
245	0	0	_aSpanish national registry of celiac disease: incidence and clinical presentation. _h[artículo]
260			_bJournal of pediatric gastroenterology and nutrition, _c2014
300			_a59(4):522-6.
500			_aFormato Vancouver: Cilleruelo ML, Román Riechmann E, Sánchez Valverde F, Donat E, Manuel Ramos J, Martín Orte E et al. Spanish national registry of celiac disease: incidence and clinical presentation. J Pediatr Gastroenterol Nutr. 2014 Oct;59(4):522-6.
501			_aPMID: 24886992
504			_aContiene 33 referencias
520			_aObjectives: The aim of this study was to assess the incidence and clinical pattern of celiac disease (CD) presently diagnosed in Spanish children. Methods: A prospective, multicenter, nationwide registry of new cases of CD in children <15 years was conducted from June 1, 2006 to May 31, 2007. The parameters studied were age at diagnosis, sex, clinical symptoms, associated diseases, nutritional status, CD serology, histological lesions, and HLA-DQ2/-DQ8. The crude incidence rate of CD was calculated as new cases per 1000 live births and as new cases per 100,000 person-years <15 years of age. Results: A total of 974 new cases of CD were included. The median age at diagnosis was 2.3 years; 39.5% of CD diagnoses occurred in the first 2 years, 42% between 2 and 6, and 18.4% from 6 to 15. Total number of cases in each age group was 385, 409, and 180, respectively. Regarding clinical presentation 70.9% showed classical symptoms, 21.9% were nonclassical, and 7% were asymptomatic. A total of 95.7% of 931, 94.7% of 611, and 86.7% of 651 children tested positive, respectively, for immunoglobulin A (IgA) anti-transglutaminase type 2 antibodies, IgA endomysial antibodies, and IgA anti-gliadin antibodies. Villous atrophy was observed in 92.4% and increased intraepithelial lymphocytes with crypt hyperplasia in 3.3%. Of the children, 55% had normal growth, and 3.4% were overweight. The HLA phenotype was DQ2: 88.3%, DQ2/DQ8: 8.4%, and DQ8: 2.3%. The incidence rate was 7.9 cases of CD per 1000 live births and 54 cases per 100,000 person-years. Conclusions: In Spain, the most frequent clinical presentation of CD is the classical form, mainly diagnosed during the first 2 years of life. The observed incidence of CD in Spanish children is much higher than the present CD incidence rates observed in other European countries.
710			_9446 _aServicio de Pediatría-Neonatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16609.pdf _ySolicitar documento
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