000			nab a22 7a 4500
999			_c16623 _d16623
003			PC16623
005			20211026115159.0
008			211026b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9443 _aRojo Conejo, Pablo _ePediatría
100			_91178 _aBlázquez Gamero, Daniel _ePediatría
245	0	0	_aSubclinical atherosclerosis and markers of immune activation in HIV-infected children and adolescents: the CaroVIH Study. _h[artículo]
260			_bJournal of acquired immune deficiency syndromes (1999), _c2014
300			_a65(1):42-9.
500			_aFormato Vancouver: Sainz T, Álvárez Fuente M, Navarro ML, Díaz L, Rojo P, Blázquez D et al; Madrid Cohort of HIV-infected children and adolescents integrated in the Pediatric branch of the Spanish National AIDS Network (CoRISPE). Subclinical atherosclerosis and markers of immune activation in HIV-infected children and adolescents: the CaroVIH Study. J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):42-9.
501			_aPMID: 23982657
504			_aContiene 45 referencias
520			_aBackground: HIV-infected adults display increased cardiovascular disease, probably driven by inflammation and immune activation. These relationships have not been addressed in vertically HIV-infected children and adolescents, a population at very high risk for long-term non-AIDS complications. Methods: Carotid intima media thickness (IMT) was measured in a cohort of HIV-infected children and adolescents and healthy controls. C-reactive protein and markers of immune activation (CD38⁺HLA-DR⁺) and immune senescence (CD28⁻CD57⁺) were determined. Results: One hundred fifty HIV-infected patients and 150 controls were included, 64.8% female. IMT was thicker in HIV-infected patients (0.434 mm ± 0.025 vs. 0.424 mm ± 0.018, P < 0.001). After adjustment by age, sex, body mass index, and smoking status, HIV infection was independently associated with thicker IMT (odds ratio, 2.28; 95% confidence interval: 1.25 to 4.13; P = 0.007). Among HIV-related variables, a low CD4 nadir was related to an increased IMT. Although HIV-infected subjects presented higher frequencies of activated CD4⁺ and CD8⁺ T cells (P = 0.002 and P = 0.087, respectively), no relation was found between IMT and inflammation, immune activation, or senescence. Conclusions: Structural changes of the vasculature present early in vertically HIV-infected subjects as well as immune activation and senescence. These patients should be carefully monitored for the prompt detection and early treatment of cardiovascular disease.
710			_9446 _aServicio de Pediatría-Neonatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16623.pdf _ySolicitar documento
942			_2ddc _cART _n0