000			nab a22 7a 4500
999			_c16738 _d16738
003			PC16738
005			20220302124603.0
008			220302b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92999 _aSanchis Gomar, Fabián _eInstituto de Investigación imas12
100			_93000 _aPareja Galeano, Helios _eInstituto de Investigación imas12
100			_92658 _aSantos Lozano, Alejandro _eInstituto de Investigación i+12
100			_92657 _aGaratachea, Nuria _eInstituto de Investigación i+12
100			_92430 _aFiuza Luces, Carmen _eInstituto de Investigación i+12
100			_92429 _aLucía, Alejandro _eInstituto de Investigación i+12
245	0	2	_aA preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. _h[artículo]
260			_bAge (Dordrecht, Netherlands), _c2015
300			_a37(3):9776.
500			_aFormato Vancouver: Sanchis Gomar F, Pareja Galeano H, Santos Lozano A, Garatachea N, Fiuza Luces C, Venturini L et al. A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. Age (Dordr). 2015 Jun;37(3):9776.
501			_aPMID: 25911468 PMCID: PMC4409588
504			_aContiene 37 referencias
520			_aAlthough the number of centenarians is growing worldwide, the potential factors influencing the aging process remain only partially elucidated. Researchers are increasingly focusing toward biomarkers as tools to shed more light on the pathophysiology of complex phenotypes, including the ability to reach successful aging, i.e., free of major chronic diseases. We therefore conducted a case-control study examining the potential associations of multiple candidate biomarkers in healthy centenarians and sex-matched healthy elderly controls. Using a case-control study of 81 centenarians (aged ≥ 100 years) selected based on the fact that they were disease-free and 46 healthy elderly controls (aged 70-80 years), serum levels of 15 different candidate biomarkers involved in the regulation of metabolism, angiogenesis, inflammation, and bone formation were measured. Of the 15 biomarkers tested, four molecules (chemerin, fetuin-A, and fibroblast growth factors [FGF] 19 and 21) were found to be independently associated with successful aging regardless of sex. Logistic regression analysis confirmed that chemerin, fetuin-A, FGF19, and FGF21 were independently associated with successful aging [predicted probability (PP) = 1 / [1 + 1 / exp (11.832 - 0.027 × (chemerin) - 0.009 × (fetuin-A) + 0.014 × (FGF19) - 0.007 × (FGF21)]. The area under the curve (AUC) of predicted probability values for the four-biomarker panel revealed that it can discriminate between centenarians and elderly controls with excellent accuracy (AUC > 0.94, P < 0.001). Although preliminary in essence and limited by the low sample size and lack of replication in other independent cohorts, our data suggest an independent association between successful aging and serum chemerin, fetuin-A, FGF19, and FGF21, which may provide novel information on the mechanisms behind the human aging process. Whether the four-biomarker panel may predict successful aging deserves further scrutiny.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409588/ _yAcceso libre
942			_2ddc _cART _n0