000			nab a22 7a 4500
999			_c16880 _d16880
003			PC16880
005			20220531095014.0
008			220531b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92408 _aCuartero, María Isabel _eInstituto de Investigación i+12
100			_92407 _aBallesteros, Iván _eInstituto de Investigación i+12
100			_92410 _aLizasoain, Ignacio _eInstituto de Investigación i+12
100			_92409 _aMoro, María A _eInstituto de Investigación i+12
245	0	0	_aComplexity of the cell-cell interactions in the innate immune response after cerebral ischemia. _h[artículo]
260			_bBrain research, _c2015
300			_a1623:53-62.
500			_aFormato Vancouver: Cuartero MI, Ballesteros I, Lizasoain I, Moro MA. Complexity of the cell-cell interactions in the innate immune response after cerebral ischemia. Brain Res. 2015 Oct 14;1623:53-62.
501			_aPMID: 25956207
504			_aContiene 109 referencias
520			_aIn response to brain ischemia a cascade of signals leads to the activation of the brain innate immune system and to the recruitment of blood borne derived cells to the ischemic tissue. These processes have been increasingly shown to play a role on stroke pathogenesis. Here, we discuss the key features of resident microglia and different leukocyte subsets implicated in cerebral ischemia with special emphasis of neutrophils, monocytes and microglia. We focus on how leukocytes are recruited to injured brain through a complex interplay between endothelial cells, platelets and leukocytes and describe different strategies used to inhibit their recruitment. Finally, we discuss the possible existence of different leukocyte subsets in the ischemic tissue and the repercussion of different myeloid phenotypes on stroke outcome. The knowledge of the nature of these heterogeneous cell-cell interactions may open new lines of investigation on new therapies to promote protective immune responses and tissue repair after cerebral ischemia or to block harmful responses. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16880.pdf _ySolicitar documento
942			_2ddc _cART _n0