000			nab a22 7a 4500
999			_c16883 _d16883
003			PC16883
005			20220601115856.0
008			220601b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9467 _aCarreira Delgado, Patricia Esmeralda _eReumatología
245	0	0	_aConfirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis. _h[artículo]
260			_bClinical and experimental rheumatology, _c2015
300			_a33(4 Suppl 91):S31-5.
500			_aFormato Vancouver: Ochoa E, Martín JE, Assasi S, Beretta L, Carreira P, Guillén A et al; Spanish Scleroderma Group. Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S31-5.
501			_aPMID: 26314374
504			_aContiene 20 referencias
520			_aObjectives: The current knowledge of the influence of systemic sclerosis (SSc) risk loci in the clinical sub-phenotypes is still limited. The main limitation lies in the low frequency of some sub-phenotypes which could be solved by replication studies in independent cohorts and meta-analysis between studies. In this regard, CCR6 gene variants have been recently associated with anti-topoisomerase I positive (ATA+) production in SSc patients in a candidate gene study. This gene has been proposed to have a critical role in IL-17-driven autoimmunity in human diseases. Methods: In order to confirm the association between CCR6 and ATA+ SSc patients, we performed an independent replication study in populations of European ancestry. We studied two CCR6 genetic variants (rs968334 and rs3093024) in a total of 901 ATA+ SSc cases, 3,258 ATA- SSc cases and 7,865 healthy controls and compared allelic frequencies for those SNPs in ATA+ SSc with healthy controls and also with ATA- SSc patients. Results: The comparison performed between ATA+ SSc patients and healthy controls showed significant association with SNP rs968334 (p=4.88x10(-2), OR=1.11). When we compared ATA+ SSc cases with ATA- SSc, both SNPs, rs3093024 and rs968334, showed significant associations (p=2.89x10(-2), OR=1.13; p=1.69x10(-2), OR=1.15). Finally, in order to increase even more sample size and statistical power, we meta-analysed our study with the previous reported and found a significant association between SNP rs3093024 and ATA+ SSc patients (p=1.00x10(-4), OR=1.16) comparing with healthy controls.
710			_9123 _aServicio de Reumatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16883.pdf _ySolicitar documento
942			_2ddc _cART _n0