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100			_92359 _aBrañas García, Patricia María _eMicrobiología y Parasitología
100			_91178 _aBlázquez Gamero, Daniel _ePediatría
100			_9896 _aGalindo Izquierdo, Alberto _eObstetricia y Ginecología
100			_93068 _aPrieto, Columbiana _eInstituto de Investigación imas12
100			_91017 _aFolgueira López, María Dolores _eMicrobiología y Parasitología
245	0	0	_aCytomegalovirus Genotype Distribution Among Congenitally and Postnatally Infected Patients: Association of Particular Glycoprotein (g)B and gN Types With Symptomatic Disease. _h[artículo]
260			_bOpen forum infectious diseases, _c2015
300			_a2(4):ofv151.
500			_aFormato Vancouver: Brañas P, Blázquez Gamero D, Galindo A, Prieto C, Olabarrieta I, Cuadrado I et al. Cytomegalovirus Genotype Distribution Among Congenitally and Postnatally Infected Patients: Association of Particular Glycoprotein (g)B and gN Types With Symptomatic Disease. Open Forum Infect Dis. 2015 Oct 7;2(4):ofv151.
501			_aPMID: 26613094 PMC4653958
504			_aContiene 41 referencias
520			_aBackground. Human cytomegalovirus is a leading cause of congenital infection, and there are limited data on prognosis markers in disease development. We aimed to study 3 virology targets (glycoprotein [g]B, gN, and UL144) to assess their correlation with congenital infection and various organ system involvement. Methods. Forty-eight congenital cases and 58 postnatally infected children were included (2003-2014). Genotyping for the 3 targets and distribution among the cohorts were investigated, and the relationship between the gB, gN, and UL144 types with clinical manifestations in congenital infection was also studied. Results. All of the genotypes were similarly represented among cohorts, and the most prevalent were the UL144B, gB1, and gN1 genotypes. The gB2 genotype was associated with abnormal image findings by ultrasound and/or magnetic resonance in congenital infection (odds ratio [OR], 6.2; 95% confidence interval [CI], 1.1-34.3; P = .036); the gN1 genotype was associated with an elevated risk of developing neurological disorders (OR, 7.0; 95% CI, 1.1-45.9; P = .043). Both gN1 and gB2 were independent factors for symptomatic infection. Statistical analyses showed no association between any UL144 genotype and disease severity. Conclusions. All of the genotypes can be involved in congenital infection, although the gB2 and gN1 genotypes might be associated with a more serious illness.
710			_981 _aServicio de Microbiología y Parasitología
710			_9446 _aServicio de Pediatría-Neonatología
710			_9427 _aServicio de Obstetricia y Ginecología
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653958/ _yAcceso libre
942			_2ddc _cART _n0