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_c16937 _d16937 |
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003 | PC16937 | ||
005 | 20220708120758.0 | ||
008 | 220708b xxu||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_983 _aMorales Ruiz, Enrique _eNefrología |
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_9286 _aCaro Espada, Paula Jara _eNefrología |
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_9417 _aGutiérrez Martínez, Eduardo _eNefrología |
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_9285 _aSevillano Prieto, Ángel Manuel _eNefrología |
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_92305 _aAuñón Rubio, Pilar _eNefrología |
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_91488 _aPraga Terente, Manuel _eNefrología |
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_aDiverse diuretics regimens differentially enhance the antialbuminuric effect of renin-angiotensin blockers in patients with chronic kidney disease. _h[artículo] |
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_bKidney international, _c2015 |
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300 | _a88(6):1434-1441. | ||
500 | _aFormato Vancouver: Morales E, Caro J, Gutiérrez E, Sevillano A, Auñón P, Fernandez C et al. Diverse diuretics regimens differentially enhance the antialbuminuric effect of renin-angiotensin blockers in patients with chronic kidney disease. Kidney Int. 2015 Dec;88(6):1434-1441. | ||
501 | _aPMID: 26308670 | ||
504 | _aContiene 38 referencias | ||
520 | _aThe addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochlorothiazide (50 mg/day) without/with amiloride (5 mg/day) on top of enalapril treatment in 21 patients with CKD stages 1-3 and a urinary albumin-to-creatinine ratio (UACR) over 300 mg/g. Treatment periods lasted 4 weeks. The UACR showed a significant reduction with the diuretics: spironolactone, -34% or hydrochlorothiazide without/with amiloride -42% or -56%, respectively. Reduction of the UACR was significantly greater with hydrochlorothiazide without/with amiloride when compared with spironolactone. The percentage of patients who achieved UACR reductions greater than 30% and 50% was greater with hydrochlorothiazide without/with amiloride (81% and 57%, and 81% and 66%, respectively) when compared with spironolactone alone (57% and 28%, respectively). Glomerular filtration rate (GFR), blood pressure, and body weight decreased with the three diuretic regimens. A significant correlation was found between the UACR reduction and GFR and blood pressure changes. Thus, diverse diuretic regimens differentially enhance albuminuria reduction, an effect likely associated with the degree of GFR reduction. | ||
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_986 _aServicio de Nefrología |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16937.pdf _ySolicitar documento |
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