000			nab a22 7a 4500
999			_c17001 _d17001
003			PC17001
005			20221006105459.0
008			221006b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92577 _aKrzyzanowska, Agnieszka _eInstituto de Investigación i+12
100			_91867 _aGarcía-Consuegra Galiana, Inés _eInstituto de Investigación i+12
100			_92349 _aPascual, Consuelo _eInstituto de Investigación i+12
100			_92134 _aAntequera, Desiree _eInstituto de Investigación i+12
100			_91777 _aCarro Díaz, Eva _eInstituto de Investigación i+12
245	0	0	_aExpression of regulatory proteins in choroid plexus changes in early stages of Alzheimer disease. _h[artículo]
260			_bJournal of neuropathology and experimental neurology, _c2015
300			_a74(4):359-69.
500			_aFormato Vancouver: Krzyzanowska A, García Consuegra I, Pascual C, Antequera D, Ferrer I, Carro E. Expression of regulatory proteins in choroid plexus changes in early stages of Alzheimer disease. J Neuropathol Exp Neurol. 2015 Apr;74(4):359-69.
501			_aPMID: 25756589
504			_aContiene 44 referencias
520			_aRecent studies indicate that the choroid plexus has important physiologic and pathologic roles in Alzheimer disease (AD). To obtain additional insight on choroid plexus function, we performed a proteomic analysis of choroid plexus samples from patients with AD stages I to II (n = 16), III to IV (n = 16), and V to VI (n = 11) and 7 age-matched control subjects. We used 2-dimensional differential gel electrophoresis coupled with mass spectrometry to generate a complete picture of changes in choroid plexus protein expression occurring in AD patients. We identified 6 proteins: 14-3-3 β/α, 14-3-3 ε, moesin, proteasome activator complex subunit 1, annexin V, and aldehyde dehydrogenase, which were significantly regulated in AD patient samples (p < 0.05, >1.5-fold variation in expression vs control samples). These proteins are implicated in major physiologic functions including mitochondrial dysfunction and apoptosis regulation. These findings contribute additional significance to the emerging importance of molecular and functional changes of choroid plexus function in the pathophysiology of AD.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17001.pdf _ySolicitar documento
942			_2ddc _cART _n0