000			nab a22 7a 4500
999			_c17014 _d17014
003			PC17014
005			20221014062800.0
008			221013b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92385 _aJoven Ibáñez, Beatriz Esther _eReumatología
100			_9467 _aCarreira Delgado, Patricia Esmeralda _eReumatología
245	0	0	_aFCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors. _h[artículo]
260			_bPharmacogenomics, _c2015
300			_a16(4):333-45.
500			_aFormato Vancouver: Montes A, Pérez Pampin E, Joven B, Carreira P, Fernández Nebro A, Del Carmen Ordóñez M et al. FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors. Pharmacogenomics. 2015;16(4):333-45.
501			_aPMID: 25823782
504			_aContiene 57 referencias
520			_aObjectives: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other FcγR functional polymorphisms. Methods: Functional polymorphisms FCGR3A F158V, FCGR2B I223T and promoter VNTR in FCGRT were analyzed in up to 429 patients with RA. Response to TNFi was recorded during standard care at 3, 6 and 12 months of follow-up. Fixed effects meta-analysis of studies addressing FCGR3A F158V polymorphism, which is the most studied of these polymorphisms, was conducted with inverse variance weighting. Results: None of the functional polymorphisms were associated with change in DAS28. Meta-analysis of the seven studies (899 patients) with available data addressing association of FCGR3A F158V with response to TNFi in RA showed no association (OR: 1.11, 95% CI: 0.8-1.5; p = 0.5). Conclusion: None of the three functional polymorphisms in FcγR genes showed association with response to TNFi in patients with RA. These negative results were obtained in spite of the larger size of this study relative to previous studies addressing the same polymorphisms. In addition, meta-analysis of FCGR3A F158V was also negative against the results provided by previous studies. Original submitted 17 September 2014; Revision submitted 9 December 2014.
710			_9123 _aServicio de Reumatología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17014.pdf _ySolicitar documento
942			_2ddc _cART _n0