000			nab a22 7a 4500
999			_c17023 _d17023
003			PC17023
005			20221017103157.0
008			221017b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aspa
100			_9892 _aBenito León, Julián _eNeurología
245	0	0	_aPrimer caso descrito de parálisis aislada, completa y fluctuante del III nervio craneal como forma de inicio de un mieloma múltiple. _h[revisión]
260			_bRevista de neurología, _c2015
300			_a60(3):115-9.
500			_aFormato Vancouver: León Ruiz M, Benito León J, Sierra Hidalgo F, García Soldevilla MÁ, Izquierdo Esteban L, Tejeiro Martínez J et al. Primer caso descrito de parálisis aislada, completa y fluctuante del III nervio craneal como forma de inicio de un mieloma múltiple. Rev Neurol. 2015 Feb 1;60(3):115-9.
501			_aPMID: 25624087
504			_aContiene 27 referencias
520			_aIntroduction: Multiple myeloma is the most common plasma-cell malignancy. To be incurable, treatment aims to obtain the longest non-clinical survival time. Cranial nerve palsy in multiple myeloma is extremely rare and is usually due to an intracranial plasmacytoma. We present a multiple myeloma case, with an intracranial plasmacytoma, which debuted clinically with isolated, complete and fluctuating cranial nerve III palsy. Case report: A 63-year-old woman presented an oscillating clinical picture, consisting of horizontal binocular diplopia and later, headache. The neuro-ophthalmologic examination revealed a complete cranial nerve III palsy of the right eye. An urgent cranial CT-scan was requested. It showed multiple diploic osteolytic lesions, associating soft-parts component in the right superior orbital fissure. The patient was admitted, being diagnosed subsequently of IgA-kappa multiple myeloma. After receiving induction-chemotherapy and undergoing autologous stem cell transplantation, she achieved full remission. Conclusions: Multiple myeloma is a rare cranial nerves disorder, very uncommon cause of cranial nerve III full isolated paralysis and even less fluctuating, not having found any case published with this clinical onset. Awareness of possible multiple myeloma neuro-ophthalmic manifestations may bring about an early diagnosis and a positive impact on the disease course.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17022.pdf _ySolicitar documento
942			_2ddc _cREV _n0