000			nab a22 7a 4500
999			_c17052 _d17052
003			PC17052
005			20221104135316.0
008			221104b xxu||||| |||| 00| 0 eng d
040			_cH12O
100			_9892 _aBenito León, Julián _eNeurología
245	0	0	_aHeme Oxygenase 1 and 2 Common Genetic Variants and Risk for Essential Tremor. _h[artículo]
260			_bMedicine (Baltimore), _c2015
300			_a94(24):e968.
500			_aFormato Vancouver: Ayuso P, Agúndez JAG, Alonso Navarro H, Martínez C, Benito León J, Ortega Cubero S et al. Heme Oxygenase 1 and 2 Common Genetic Variants and Risk for Essential Tremor. Medicine (Baltimore). 2015 Jun;94(24):e968.
501			_aPMID: 26091465 PMC4616553
504			_aContiene 33 referencias
520			_aSeveral reports suggested a role of heme oxygenase genes 1 and 2 (HMOX1 and HMOX2) in modifying the risk to develop Parkinson disease (PD). Because essential tremor (ET) and PD share phenotypical and, probably, etiologic factors of the similarities, we analyzed whether such genes are related with the risk to develop ET. We analyzed the distribution of allelic and genotype frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 single nucleotide polymorphisms, as well as the presence of copy number variations of these genes in 202 subjects with familial ET and 747 healthy controls. Allelic frequencies of rs2071746T and rs1051308G were significantly lower in ET patients than in controls. None of the studied polymorphisms influenced the disease onset. The present study suggests a weak association between HMOX1 rs2071746 and HMOX2 rs1051308 polymorphisms and the risk to develop ET in the Spanish population.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616553/ _yAcceso libre
942			_2ddc _cART _n0