000			02393na a2200241 4500
003			PC1708
005			20210625062757.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBolos, Marta _92135 _eInstituto de Investigación i+12
100			_aCarro Díaz, Eva _91777 _eInstituto de Investigación i+12
245	0	0	_aNeurogenic effects of β-amyloid in the choroid plexus epithelial cells in Alzheimer's disease. _h[artículo]
260			_bCellular and molecular life sciences: CMLS, _c2013
300			_a70(15):2787-97.
500			_aFormato Vancouver: Bolos M, Spuch C, Ordóñez-Gutiérrez L, Wandosell F, Ferrer I, Carro E. Neurogenic effects of β-amyloid in the choroid plexus epithelial cells in Alzheimer's disease. Cell Mol Life Sci. 2013 Aug;70(15):2787-97.
501			_aPMID: 23455075
504			_aContiene 57 referencias
520			_aβ-amyloid (Aβ) can promote neurogenesis, both in vitro and in vivo, by inducing neural progenitor cells to differentiate into neurons. The choroid plexus in Alzheimer's disease (AD) is burdened with amyloid deposits and hosts neuronal progenitor cells. However, neurogenesis in this brain tissue is not firmly established. To investigate this issue further, we examined the effect of Aβ on the neuronal differentiation of choroid plexus epithelial cells in several experimental models of AD. Here we show that Aβ regulates neurogenesis in vitro in cultured choroid plexus epithelial cells as well as in vivo in the choroid plexus of APP/Ps1 mice. Treatment with oligomeric Aβ increased proliferation and differentiation of neuronal progenitor cells in cultured choroid plexus epithelial cells, but decreased survival of newly born neurons. These Aβ-induced neurogenic effects were also observed in choroid plexus of APP/PS1 mice, and detected also in autopsy tissue from AD patients. Analysis of signaling pathways revealed that pre-treating the choroid plexus epithelial cells with specific inhibitors of TyrK or MAPK diminished Aβ-induced neuronal proliferation. Taken together, our results support a role of Aβ in proliferation and differentiation in the choroid plexus epithelial cells in Alzheimer's disease.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc1708.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c1708 _d1708