000			nab a22 7a 4500
999			_c17131 _d17131
003			PC17131
005			20221222134108.0
008			221222b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aspa
100			_9559 _aMarcacuzco Quinto, Alberto _eCirugía General y Aparato Digestivo
100			_9360 _aManrique Municio, Alejandro _eCirugía General y del Aparato Digestivo
100			_9358 _aJiménez Romero, Carlos _eCirugía General y del Aparato Digestivo
100			_9558 _aLoinaz Segurola, Carmelo _eCirugía General y del Aparato Digestivo
100			_9557 _aCalvo Pulido, Jorge _eCirugía General y del Aparato Digestivo
100			_9282 _aJusto Alonso, Iago _eCirugía General y del Aparato Digestivo
100			_9556 _aGarcía-Sesma Pérez-Fuentes, Álvaro _eCirugía General y del Aparato Digestivo
100			_9560 _aAbradelo de Usera, Manuel _eCirugía General y Aparato Digestivo
100			_9552 _aCambra Molero, Félix _eCirugía General y del Aparato Digestivo
100			_9554 _aCaso Maestro, Óscar _eCirugía General y del Aparato Digestivo
100			_9510 _aMoreno González, Enrique _eCirugía General y del Aparato Digestivo
245	0	0	_aTrasplante hepático como tratamiento de la polineuropatía amiloidótica familiar en pacientes mayores de 60 años. _h[artículo]
260			_bMedicina clínica, _c2015
300			_a144(9):385-8.
500			_aFormato Vancouver: Marcacuzco Quinto AA, Manrique Municio A, Jiménez Romero LC, Loinaz Segurola C, Calvo Pulido J, Justo Alonso I et al. Trasplante hepático como tratamiento de la polineuropatía amiloidótica familiar en pacientes mayores de 60 años. Med Clin (Barc). 2015 May 8;144(9):385-8.
501			_aPMID: 24746275
504			_aContiene 30 referencias
520			_aBackground and objective: Familial amyloid polyneuropathy (FAP) is the most prevalent type of hereditary systemic amyloidosis. It is an autosomal dominant disease characterized by the deposition of an abnormal variant transthyretin. It has a worldwide distribution, with localized endemic areas in Portugal, Sweden and Japan. In Spain there is an endemic focus, located in Mallorca. Liver transplantation is the only curative option for patients with FAP. The aim of this study was to describe the clinical and demographic characteristics of patients transplanted with a diagnosis of PAF. Material and method: Six patients with PAF underwent liver transplantation between April 1986 and December 2012. Results: The mean age was 57.7+16 years, patients of Spanish origin were older than 60 years. All patients had progressive symptoms as mixed polyneuropathy. In 2 patients, combined heart-liver transplants sequentially were performed. Patient survival and graft was 80% at one, 3 and 5 years. Conclusions: The only effective treatment for etiologic PAF is liver transplantation. Early detection is the key to the treatment and control, avoiding the irreversible organ damage.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17131.pdf _ySolicitar documento
942			_2ddc _cART _n0