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_c17139 _d17139 |
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003 | PC17139 | ||
005 | 20230123131456.0 | ||
008 | 230123b xxu||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
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_93126 _aGuisasola, Eduardo _eInstituto de Investigación imas12 |
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_92995 _aBaeza, Alejandro _eInstituto de Investigación imas12 |
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_93127 _aTalelli, Marina _eInstituto de Investigación imas12 |
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_92843 _aArcos, Daniel _eInstituto de Investigación imas12 |
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_92644 _aVallet Regí, María _eInstituto de Investigación imas12 |
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_aMagnetic-Responsive Release Controlled by Hot Spot Effect. _h[artículo] |
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_bLangmuir : the ACS journal of surfaces and colloids, _c2015 |
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300 | _a31(46):12777-82. | ||
500 | _aFormato Vancouver: Guisasola E, Baeza A, Talelli M, Arcos D, Moros M, de la Fuente JM et al. Magnetic-Responsive Release Controlled by Hot Spot Effect. Langmuir. 2015 Nov 24;31(46):12777-82. | ||
501 | _aPMID: 26536300 | ||
504 | _aContiene 31 referencias | ||
520 | _aMagnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of magnetic cores to generate thermal energy in the presence of an alternating magnetic field. Then, the temperature increase triggers the drug release. Despite this potential, the rapid heat dissipation in living tissues is a serious hindrance for their clinical application. It is hypothesized that magnetic cores could act as hot spots, this is, produce enough heat to trigger the release without the necessity to increase the global temperature. Herein, a nanocarrier has been designed to respond when the temperature reaches 43 °C. This material has been able to release its payload under an alternating magnetic field without the need of increasing the global temperature of the environment, proving the efficacy of the hot spot mechanism in magnetic-responsive drug delivery devices. | ||
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_9625 _aInstituto de Investigación imas12 |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17139.pdf _ySolicitar documento |
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_2ddc _cART _n0 |