000			nab a22 7a 4500
999			_c17260 _d17260
003			PC17260
005			20230224124706.0
008			230224b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92031 _aHuerta Arroyo, Ana María _eNefrología
245	0	0	_aPredictors of outcome for severe IgA nephropathy in a multi-ethnic US cohort. _h[artículo]
260			_bClinical nephrology, _c2015
300			_a84(3):145-55.
500			_aFormato Vancouver: Arroyo AH, Bomback AS, Butler B, Radhakrishnan J, Herlitz L, Stokes MB et al. Predictors of outcome for severe IgA Nephropathy in a multi-ethnic U.S. cohort. Clin Nephrol. 2015 Sep;84(3):145-55.
501			_a PMID: 26226949
504			_aContiene 42 referencias
520			_aBackground: Although IgA nephropathy (IgAN) is the leading cause of glomerulonephritis worldwide, there are few large cohorts representative of U.S. Populations: Prognosis remains challenging, particularly as more patients are treated with RAAS blockade and immunosuppression. Methods: We analyzed a retrospective cohort of IgAN patients followed at Columbia University Medical Center from 1980 to 2010. We evaluated two outcomes - halving of eGFR and ESRD - using three proportional hazards models: 1) a model with only clinical parameters, 2) a model with only histopathologic parameters, and 3) a model combining clinical and histopathologic parameters. Results: Of 154 patients with biopsy-proven IgAN, 126 had follow-up data available and 93 had biopsy slides re-read. Median follow-up was 47 months. The cohort was 64% male, 60% white, and the average age was 34 years at diagnosis. Median (IQR) eGFR and proteinuria at diagnosis were 64.1 (38.0 - 88.7) mL/min/1.73 m2 and 2.7 (1.3 - 4.5) g/day. Over 90% of subjects were treated with RAAS blockade, and over 66% received immunosuppression. In the clinical parameters-only model, baseline eGFR and African-American race predicted both halving of eGFR and ESRD. In the histopathologic parameters-only model, no parameter significantly predicted outcome. In the combined model, baseline eGFR remained the strongest predictor of both halving of eGFR (p = 0.03) and ESRD (p = 0.001), while the presence of IgG by immunofluorescence microscopy also predicted progression to ESRD. Conclusion: In this diverse U.S. IgAN cohort in which the majority of patients received RAAS blockade and immunosuppression, baseline eGFR, African-American race, and co-staining of IgG predicted poor outcome.
710			_986 _aServicio de Nefrología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17260.pdf _ySolicitar documento
942			_2ddc _cART _n0