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_c17349 _d17349 |
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003 | PC17349 | ||
005 | 20230329133955.0 | ||
008 | 230329b xxu||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_9891 _aVanaclocha Sebastián, Francisco _eDermatología Médico Quirúrgica y Venereología |
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245 | 0 | 0 |
_aSecukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. _h[artículo] |
260 |
_bJournal of the American Academy of Dermatology, _c2015 |
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300 | _a73(3):400-9. | ||
500 | _aFormato Vancouver: Thaçi D, Blauvelt A, Reich K, Tsai TF, Vanaclocha F, Kingo K et al. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. J Am Acad Dermatol. 2015 Sep;73(3):400-9. | ||
501 | _aPMID: 26092291 | ||
504 | _aContiene 28 referencias | ||
520 | _aBackground: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has shown superior efficacy to etanercept with similar safety in moderate to severe plaque psoriasis (FIXTURE study). Objective: We sought to directly compare efficacy and safety of secukinumab versus ustekinumab. Methods: In this 52-week, double-blind study (NCT02074982), 676 subjects were randomized 1:1 to subcutaneous injection of secukinumab 300 mg or ustekinumab per label. Primary end point was 90% or more improvement from baseline Psoriasis Area and Severity Index (PASI) score (PASI 90) at week 16. Results: Secukinumab (79.0%) was superior to ustekinumab (57.6%) as assessed by PASI 90 response at week 16 (P < .0001). The 100% improvement from baseline PASI score at week 16 was also significantly greater with secukinumab (44.3%) than ustekinumab (28.4%) (P < .0001). The 75% or more improvement from baseline PASI score at week 4 was superior for secukinumab (50.0%) versus ustekinumab (20.6%) (P < .0001). Percentage of subjects with the Dermatology Life Quality Index score 0/1 (week 16) was significantly higher with secukinumab (71.9%) than ustekinumab (57.4%) (P < .0001). The safety profile of secukinumab was comparable with ustekinumab and consistent with pivotal phase III secukinumab studies. Limitations: The study was not placebo-controlled and of short-term duration. Conclusions: Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe psoriasis and improving health-related quality of life with a comparable safety profile over 16 weeks. | ||
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_9145 _aServicio de Dermatología Médico-Quirúrgica y Venereología |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17349.pdf _ySolicitar documento |
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_2ddc _cART _n0 |