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040			_cH12O
041			_aeng
100			_9892 _aBenito León, Julián _eNeurología
100			_93260 _aRomero, Juan P. _eNeurología
245	0	4	_aThe phase difference between neural drives to antagonist muscles in essential tremor is associated with the relative strength of supraspinal and afferent input. _h[artículo]
260			_bThe Journal of neuroscience : the official journal of the Society for Neuroscience. _c2015
300			_a35(23):8925-37.
500			_aFormato Vancouver: Gallego JA, Dideriksen JL, Holobar A, Ibáñez J, Glaser V, Romero JP et al. The phase difference between neural drives to antagonist muscles in essential tremor is associated with the relative strength of supraspinal and afferent input. J Neurosci. 2015 Jun 10;35(23):8925-37.
501			_aPMID: 26063924 PMC6605200
504			_aContiene 115 referencias
520			_aThe pathophysiology of essential tremor (ET), the most common movement disorder, is not fully understood. We investigated which factors determine the variability in the phase difference between neural drives to antagonist muscles, a long-standing observation yet unexplained. We used a computational model to simulate the effects of different levels of voluntary and tremulous synaptic input to antagonistic motoneuron pools on the tremor. We compared these simulations to data from 11 human ET patients. In both analyses, the neural drive to muscle was represented as the pooled spike trains of several motor units, which provides an accurate representation of the common synaptic input to motoneurons. The simulations showed that, for each voluntary input level, the phase difference between neural drives to antagonist muscles is determined by the relative strength of the supraspinal tremor input to the motoneuron pools. In addition, when the supraspinal tremor input to one muscle was weak or absent, Ia afferents provided significant common tremor input due to passive stretch. The simulations predicted that without a voluntary drive (rest tremor) the neural drives would be more likely in phase, while a concurrent voluntary input (postural tremor) would lead more frequently to an out-of-phase pattern. The experimental results matched these predictions, showing a significant change in phase difference between postural and rest tremor. They also indicated that the common tremor input is always shared by the antagonistic motoneuron pools, in agreement with the simulations. Our results highlight that the interplay between supraspinal input and spinal afferents is relevant for tremor generation.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605200/ _yAcceso libre
942			_2ddc _cART _n0