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999			_c17426 _d17426
003			PC17426
005			20230425125637.0
008			230425b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92807 _aDueñas, Marta _eInstituto de Investigación i+12
100			_92814 _aParamio, Jesús M. _eInstituto de Investigación i+12
245	0	4	_aThe pluripotency factor NANOG promotes the formation of squamous cell carcinomas. _h[artículo]
260			_bScientific reports, _c2015
300			_a5:10205.
500			_aFormato Vancouver: Palla AR, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez López G et al. The pluripotency factor NANOG promotes the formation of squamous cell carcinomas. Sci Rep. 2015 May 19;5:10205.
501			_aPMID: 25988972 PMC4437308
504			_aContiene 55 referencias
520			_aNANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia favours the malignant conversion of skin papillomas induced by chemical carcinogenesis, leading to increased SCC formation. Gene expression analyses in pre-malignant skin indicate that NANOG induces genes associated to epithelial-mesenchymal transition (EMT). Some of these genes are directly activated by NANOG, including EMT-associated genes Zeb1, Zeb2, Twist1, Prrx1 and miR-21. Finally, endogenous NANOG binds to the promoters of theses genes in human SCC cells and, moreover, NANOG induces EMT features in primary keratinocytes. These results provide in vivo evidence for the oncogenic role of NANOG in squamous cell carcinomas.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437308/ _yAcceso libre
942			_2ddc _cART _n0