| 000 | nab a22 7a 4500 | ||
|---|---|---|---|
| 999 |
_c17438 _d17438 |
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| 003 | PC17438 | ||
| 005 | 20230426124414.0 | ||
| 008 | 230426b xxu||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_93263 _aValín, Álvaro _eReumatología |
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| 100 |
_91010 _aPablos Álvarez, José Luis _eReumatología |
||
| 245 | 0 | 4 |
_aThe Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation. _h[revisión] |
| 260 |
_bBiomolecules, _c2015 |
||
| 300 | _a5(4):2723-57. | ||
| 500 | _aFormato Vancouver: Valin A, Pablos JL. The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation. Biomolecules. 2015 Oct 16;5(4):2723-57. | ||
| 501 | _aPMID: 26501341 PMC4693255 | ||
| 504 | _aContiene 209 referencias | ||
| 520 | _aChronic inflammation is a common process connecting pathologies that vary in their etiology and pathogenesis such as cancer, autoimmune diseases, and infections. The response of the immune system to tissue damage involves a carefully choreographed series of cellular interactions between immune and non-immune cells. In recent years, it has become clear that stromal resident cells have an essential role perpetuating the inflammatory environment and dictating in many cases the outcome of inflammatory based pathologies. Signal transduction pathways remain the main focus of study to understand how stimuli contribute to perpetuating the inflammatory response, mainly due to their potential role as therapeutic targets. However, molecular events orchestrated in the nucleus by transcription factors add additional levels of complexity and may be equally important for understanding the phenotypic differences of activated stromal components during the chronic inflammatory process. In this review, we focus on the contribution of transcription factors to the selective regulation of inducible proinflammatory genes, with special attention given to the regulation of the stromal fibroblastic cell function and response. | ||
| 710 |
_9123 _aServicio de Reumatología |
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| 710 |
_9625 _aInstituto de Investigación imas12 |
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| 856 |
_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693255/ _yAcceso libre |
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| 942 |
_2ddc _cREV _n0 |
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