000			nab a22 7a 4500
999			_c17460 _d17460
003			PC17460
005			20230518132243.0
008			230518b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93096 _aParis, J.L. _eInstituto de Investigación imas12
100			_93271 _aRomán, J _eInstituto de Investigación imas12
100			_93272 _aManzano, M _eInstituto de Investigación imas12
100			_93095 _aCabañas, M.V. _eInstituto de Investigación imas12
100			_92644 _aVallet Regí, María _eInstituto de Investigación imas12
245	0	0	_aTuning dual-drug release from composite scaffolds for bone regeneration. _h[artículo]
260			_bInternational journal of pharmaceutics, _c2015
300			_a486(1-2):30-7.
500			_aFormato Vancouver: Paris JL, Román J, Manzano M, Cabañas MV, Vallet-Regí M. Tuning dual-drug release from composite scaffolds for bone regeneration. Int J Pharm. 2015;486(1-2):30-7.
501			_aPMID: 25814035
504			_aContiene 59 referencias
520			_aThis work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (anti-inflammatory drug) were successfully incorporated in a controlled manner into three dimensional designed porous scaffolds of apatite/agarose composite. A high-performance liquid chromatography method was optimized to separate and simultaneously quantify the two drugs released from the dual-drug codelivery system. The multifunctional porous scaffolds fabricated show a very rapid delivery of anti-inflammatory (interesting to reduce inflammation after implantation), whereas the anti-osteoporotic drug showed sustained release behaviour (important to promote bone regeneration). Since ibuprofen release was faster than desired, this drug was encapsulated in chitosan spheres which were then incorporated into the scaffolds, obtaining a release profile suitable for clinical application. The results obtained open the possibility to simultaneously incorporate two or more drugs to an osseous implant in a controlled way improving it for bone healing application.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17460.pdf _ySolicitar documento
942			_2ddc _cART _n0