000			nab a22 7a 4500
999			_c17515 _d17515
003			PC17515
005			20230619114101.0
008			230619b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92429 _aLucía, Alejandro _eInstituto de Investigación i+12
245	0	0	_aACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study. _h[artículo]
260			_bBMC genomics, _c2016
300			_a17:285.
500			_aFormato Vancouver: Papadimitriou ID, Lucía A, Pitsiladis YP, Pushkarev VP, Dyatlov DA, Orekhov EF et al. ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study. BMC Genomics. 2016 Apr 13;17:285.
501			_aPMID: 27075997 PMC4831144
504			_aContiene 38 referencias
520			_aBackground: To date, studies investigating the association between ACTN3 R577X and ACE I/D gene variants and elite sprint/power performance have been limited by small cohorts from mixed sport disciplines, without quantitative measures of performance. Aim: To examine the association between these variants and sprint time in elite athletes. Methods: We collected a total of 555 best personal 100-, 200-, and 400-m times of 346 elite sprinters in a large cohort of elite Caucasian or African origin sprinters from 10 different countries. Sprinters were genotyped for ACTN3 R577X and ACE ID variants. Results: On average, male Caucasian sprinters with the ACTN3 577RR or the ACE DD genotype had faster best 200-m sprint time than their 577XX (21.19 ± 0.53 s vs. 21.86 ± 0.54 s, p = 0.016) and ACE II (21.33 ± 0.56 vs. 21.93 ± 0.67 sec, p = 0.004) counterparts and only one case of ACE II, and no cases of ACTN3 577XX, had a faster 200-m time than the 2012 London Olympics qualifying (vs. 12 qualified sprinters with 577RR or 577RX genotype). Caucasian sprinters with the ACE DD genotype had faster best 400-m sprint time than their ACE II counterparts (46.94 ± 1.19 s vs. 48.50 ± 1.07 s, p = 0.003). Using genetic models we found that the ACTN3 577R allele and ACE D allele dominant model account for 0.92 % and 1.48 % of sprint time variance, respectively. Conclusions: Despite sprint performance relying on many gene variants and environment, the % sprint time variance explained by ACE and ACTN3 is substantial at the elite level and might be the difference between a world record and only making the final.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831144/pdf/12864_2016_Article_2462.pdf _yAcceso libre
942			_2ddc _cART _n0