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008 230621b xxu||||| |||| 00| 0 eng d
040 _cH12O
041 _aeng
100 _93000
_aPareja Galeano, Helios
_eInstituto de Investigación imas12
100 _92999
_aSanchis Gomar, Fabián
_eInstituto de Investigación imas12
100 _92429
_aLucía, Alejandro
_eInstituto de Investigación i+12
245 0 0 _a 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue.
_h[revisión]
260 _bThe Journal of physiology,
_c2016
300 _a594(12):3187-207.
500 _aFormato Vancouver: Pérez LM, Pareja Galeano H, Sanchís Gomar F, Emanuele E, Lucia A, Gálvez BG. 'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue. J Physiol. 2016 Jun 15;594(12):3187-207.
501 _aPMID: 26926488; PMCID: PMC4908019
504 _aContiene 271 referencias
520 _aThe increasing ageing of our societies is accompanied by a pandemic of obesity and related cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is increasingly recognized as an important hallmark of the ageing process, which in turn contributes to metabolic alterations, multi-organ damage and a systemic pro-inflammatory state ('inflammageing'). On the other hand, obesity, the paradigm of adipose tissue dysfunction, shares numerous biological similarities with the normal ageing process such as chronic inflammation and multi-system alterations. Accordingly, understanding the interplay between accelerated ageing related to obesity and adipose tissue dysfunction is critical to gain insight into the ageing process in general as well as into the pathophysiology of obesity and other related conditions. Here we postulate the concept of 'adipaging' to illustrate the common links between ageing and obesity and the fact that, to a great extent, obese adults are prematurely aged individuals.
710 _9625
_aInstituto de Investigación imas12
856 _uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908019/pdf/TJP-594-3187.pdf
_yAcceso libre
942 _2ddc
_cREV
_n0