000			nab a22 7a 4500
999			_c17579 _d17579
003			PC17579
005			20230719121040.0
008			230719b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93317 _aMartín Hernández, David _eInstituto de Investigación imas12
100			_92439 _aCaso, Javier Rubén _eInstituto de Investigación i+12
100			_93318 _aBris, Álvaro G. _eInstituto de Investigación imas12
100			_93319 _aMaus, Sandra R. _eInstituto de Investigación imas12
100			_92628 _aMadrigal, José LM _eInstituto de Investigación i+12
100			_91897 _aGarcía Bueno, Borja _eInstituto de Investigación i+12
100			_92610 _aMacDowell, Karina S. _eInstituto de Investigación i+12
100			_91995 _aLeza, Juan Carlos _eInstituto de Investigación i+12
245	0	0	_aBacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats. _h[artículo]
260			_bNeuropharmacology, _c2016
300			_a103:122-33.
500			_aFormato Vancouver: Martín Hernández D, Caso JR, Bris ÁG, Maus SR, Madrigal JL, García Bueno B et al. Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats. Neuropharmacology. 2016 Apr;103:122-33.
501			_aPMID: 26686392
504			_aContiene 54 referencias
520			_aRecent studies have suggested that depression is accompanied by an increased intestinal permeability which would be related to the inflammatory pathophysiology of the disease. This study aimed to evaluate whether experimental depression presents with bacterial translocation that in turn can lead to the TLR-4 in the brain affecting the mitogen-activated protein kinases (MAPK) and antioxidant pathways. Male Wistar rats were exposed to chronic mild stress (CMS) and the intestinal integrity, presence of bacteria in tissues and plasma lipopolysaccharide levels were analyzed. We also studied the expression in the prefrontal cortex of activated forms of MAPK and some of their activation controllers and the effects of CMS on the antioxidant Nrf2 pathway. Our results indicate that after exposure to a CMS protocol there is increased intestinal permeability and bacterial translocation. CMS also increases the expression of the activated form of the MAPK p38 while decreasing the expression of the antioxidant transcription factor Nrf2. The actions of antibiotic administration to prevent bacterial translocation on elements of the MAPK and Nrf2 pathways indicate that the translocated bacteria are playing a role in these effects. In effect, our results propose a role of the translocated bacteria in the pathophysiology of depression through the p38 MAPK pathway which could aggravate the neuroinflammation and the oxidative/nitrosative damage present in this pathology. Moreover, our results reveal that the antioxidant factor Nrf2 and its activators may be involved in the consequences of the CMS on the brain.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17579.pdf _ySolicitar documento
942			_2ddc _cART _n0