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041			_aeng
100			_91994 _aMac-Dowell, Karina Soledad _eInstituto de Investigación i+12
100			_91897 _aGarcía Bueno, Borja _eInstituto de Investigación i+12
100			_91873 _aRodríguez Jiménez, Roberto _ePsiquiatría
100			_91995 _aLeza, Juan Carlos _eInstituto de Investigación i+12
245	0	0	_aBDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. _h[artículo]
260			_bSchizophrenia bulletin, _c2016
300			_a42(1):142-51.
500			_aFormato Vancouver: Martínez Cengotitabengoa M, MacDowell KS, Alberich S, Díaz FJ, García Bueno B, Rodríguez Jiménez R et al; FLAMM-PEPs. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. Schizophr Bull. 2016 Jan;42(1):142-51.
501			_aPMID: 26130821 PMC4681544
504			_aContiene 57 referencias
520			_aPrevious studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs.
710			_9150 _aServicio de Psiquiatría
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681544/pdf/sbv078.pdf _yAcceso libre
942			_2ddc _cART _n0