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008			231017b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9876 _aAguado García, José María _eEnfermedades Infecciosas
245	0	0	_aCommon Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis. _h[artículo]
260			_bFrontiers in microbiology, _c2016
300			_a7:1243.
500			_aFormato Vancouver: Lupiañez CB, Villaescusa MT, Carvalho A, Springer J, Lackner M, Sánchez Maldonado JM et al. Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis. Front Microbiol. 2016 Aug 12;7:1243.
501			_aPMID: 27570521 PMC4982195
504			_aContiene 95 referencias
520			_aInvasive Aspergillosis (IA) is an opportunistic infection caused by Aspergillus, a ubiquitously present airborne pathogenic mold. A growing number of studies suggest a major host genetic component in disease susceptibility. Here, we evaluated whether 14 single-nucleotide polymorphisms within NFκB1, NFκB2, RelA, RelB, Rel, and IRF4 genes influence the risk of IA in a population of 834 high-risk patients (157 IA and 677 non-IA) recruited through a collaborative effort involving the aspBIOmics consortium and four European clinical institutions. No significant overall associations between selected SNPs and the risk of IA were found in this large cohort. Although a hematopoietic stem cell transplantation (HSCT)-stratified analysis revealed that carriers of the IRF4 rs12203592T/T genotype had a six-fold increased risk of developing the infection when compared with those carrying the C allele (ORREC = 6.24, 95%CI 1.25-31.2, P = 0.026), the association of this variant with IA risk did not reach significance at experiment-wide significant threshold. In addition, we found an association of the IRF4AATC and IRF4GGTC haplotypes (not including the IRF4 rs12203592T risk allele) with a decreased risk of IA but the magnitude of the association was similar to the one observed in the single-SNP analysis, which indicated that the haplotypic effect on IA risk was likely due to the IRF4 rs12203592 SNP. Finally, no evidence of significant interactions among the genetic markers tested and the risk of IA was found. These results suggest that the SNPs on the studied genes do not have a clinically relevant impact on the risk of developing IA.
710			_96 _aServicio de Medicina Interna
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982195/pdf/fmicb-07-01243.pdf _yAcceso libre
942			_2ddc _cART _n0