000			nab a22 7a 4500
999			_c17726 _d17726
003			PC17726
005			20231027132007.0
008			231027b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92289 _aGómez Domínguez, Elena _eAparato Digestivo
245	0	0	_aDefinition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury. _h[artículo]
260			_bJournal of hepatology, _c2016
300			_a65(3):532-42.
500			_aFormato Vancouver: Medina Caliz I, Robles Diaz M, Garcia Muñoz B, Stephens C, Ortega Alonso A, Garcia Cortes M et al; Spanish DILI registry. Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury. J Hepatol. 2016 Sep;65(3):532-42.
501			_aPMID: 27184533 PMC7458366
504			_aContiene 47 referencias
520			_aBackground & aims: Chronic outcome following acute idiosyncratic drug-induced liver injury (DILI) is not yet defined. This prospective, long-term follow-up study aimed to analyze time to liver enzyme resolutions to establish the best definition and risk factors of DILI chronicity. Methods: 298 out of 850 patients in the Spanish DILI registry with no pre-existing disease affecting the liver and follow-up to resolution or ⩾1year were analyzed. Chronicity was defined as abnormal liver biochemistry, imaging test or histology one year after DILI recognition. Results: Out of 298 patients enrolled 273 (92%) resolved ⩽1year from DILI recognition and 25 patients (8%) were chronic. Independent risk factors for chronicity were older age [OR: 1.06, p=0.011], dyslipidemia [OR: 4.26, p=0.04] and severe DILI [OR: 14.22, p=0.005]. Alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (TB) median values were higher in the chronic group during follow-up. Values of ALP and TB >1.1 x upper limit of normal (xULN) and 2.8 xULN respectively, in the second month from DILI onset, were found to predict chronic DILI (p<0.001). Main drug classes involved in chronicity were statins (24%) and anti-infectives (24%). Histological examination in chronic patients demonstrated two cases with ductal lesion and seven with cirrhosis. Conclusions: One year is the best cut-off point to define chronic DILI or prolonged recovery, with risk factors being older age, dyslipidemia and severity of the acute episode. Statins are distinctly related to chronicity. ALP and TB values in the second month could help predict chronicity or very prolonged recovery.
710			_9273 _aServicio de Medicina del Aparato Digestivo
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458366/pdf/nihms-1618208.pdf _yAcceso libre
942			_2ddc _cART _n0