000			nab a22 7a 4500
999			_c17774 _d17774
003			PC17774
005			20231205130521.0
008			231205b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9648 _aDíaz Tasende, José _eAparato Digestivo
245	0	0	_aEndoscopic surveillance in patients with multiple (10-100) colorectal polyps. _h[artículo]
260			_bEndoscopy, _c2016
300			_a48(1):56-61.
500			_aFormato Vancouver: Valentín F, Guarinos C, Juárez M, Rodríguez Soler M, Serradesanferm A, Rodriguez Moranta F et al. Endoscopic surveillance in patients with multiple (10-100) colorectal polyps. Endoscopy. 2016 Jan;48(1):56-61.
501			_aPMID: 26165738
504			_aContiene 31 referencias
520			_aBackground and study aims: Endoscopic surveillance in patients with multiple colorectal polyps aims to reduce colorectal cancer (CRC) incidence and mortality, as well as the need for colorectal surgery. The aim of this study was to determine the risk of developing CRC or the need for surgery during endoscopic surveillance in a cohort of patients with multiple (10 - 100) colorectal polyps. Patients and methods: This was a multicentrer, longitudinal, observational study in 15 CRC high risk clinics in Spain, carried out between January 2009 and December 2010. Patients who were included in the EPIPOLIP trial and had at least 1 year of follow-up were included in the study. The primary outcome of interest was the incidence of CRC at least 1 year following the initial colonoscopy. The secondary outcome was the need for colorectal surgery. Results: A total of 265 patients were followed for a median of 3.8 years. Patients underwent a median of 5 colonoscopies, and 17 patients (6.4 %) were diagnosed with CRC. A total of 32 patients (12.1 %) underwent surgery, including 15 (5.7 %) for prophylaxis without a diagnosis of CRC. The corresponding incidence density rates for CRC and colorectal surgery were 1.4 (95 % confidence interval [CI] 0.7 to 2.1) and 2.7 (95 %CI 1.7 to 3.6) per 100 patient-years, respectively. Only the presence of symptoms at first colonoscopy was independently associated with CRC diagnosis (hazard ratio [HR] 7.7, 95 %CI 1.1 to 59.3) and colorectal surgery (HR 4.6, 95 %CI 1.02 to 20.6). Conclusions: Patients with more than 10 neoplastic polyps required frequent colonoscopies within a short follow-up period. More than 10 % of patients required colorectal surgery within 4 years, more than half for incident CRC.
710			_9273 _aServicio de Medicina del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17774.pdf _ySolicitar documento
942			_2ddc _cART _n0