000			nab a22 7a 4500
999			_c17841 _d17841
003			PC17841
005			20240513115915.0
008			240513b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91977 _aMartín Asenjo, Roberto _eCardiología
245	0	0	_aFrailty is a short-term prognostic marker in acute coronary syndrome of elderly patients. _h[artículo]
260			_bEuropean heart journal. Acute cardiovascular care, _c2016
300			_a5(5):434-40.
500			_aFormato Vancouver: Alonso Salinas GL, Sanmartín Fernández M, Pascual Izco M, Martín Asenjo R, Recio Mayoral A, Salvador Ramos L et al. Frailty is a short-term prognostic marker in acute coronary syndrome of elderly patients. Eur Heart J Acute Cardiovasc Care. 2016 Sep;5(5):434-40.
501			_aPMID: 27091834
504			_aContiene 29 referencias
520			_aBackground: Frailty is a biological condition that reflects a state of decreased physiological reserve and vulnerability to stressors. The role of frailty in acute coronary syndrome patients has not been fully explored. Our study aims to assess the prevalence of frailty and its impact on in-hospital adverse outcomes of patients aged ⩾75 years admitted for acute coronary syndrome. Methods: This prospective, observational study included patients aged ⩾75 years admitted due to type 1 myocardial infarction in four tertiary hospitals. Frailty was assessed by the SHARE-FI index. The primary endpoint was the combination of in-hospital death or non-fatal myocardial (re)infarction. Secondary endpoints included the assessment of individual rates of (re)infarction, mortality, stroke, major bleeding and the combination of in-hospital death, (re)infarction and mortality. Results: A total of 202 patients were analysed. Frail patients (n=71, 35.1%) were older, more often women, had higher rates of comorbidities, and a higher risk profile according to GRACE, TIMI and CRUSADE scores at admission. The primary endpoint was significantly more frequent among frail patients (9.9% vs. 1.5%; P=0.006), as well as the combination of death, myocardial infarction and stroke (11.3% vs. 1.5%; P=0.002), driven mainly by a higher mortality rate (8.5% vs 0.8%; P=0.004). On multivariate analysis, frailty phenotype was an independent predictor of major adverse cardiac events (odds ratio 7.13; 95% confidence interval 1.43-35.42). Conclusions: Over one third of elderly patients with high-risk acute coronary syndrome are frail. Frailty phenotype is an important and independent prognostic marker in these patients.
710			_9119 _aServicio de Cardiología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17841.pdf _ySolicitar documento
942			_2ddc _cART _n0