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_c17907 _d17907 |
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003 | PC17907 | ||
005 | 20240812132457.0 | ||
008 | 240812b xxu||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_942 _aFerrero Herrero, Eduardo _eCirugía General y del Aparato Digestivo |
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100 |
_9510 _aMoreno González, Enrique _eCirugía General y del Aparato Digestivo |
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245 | 0 | 0 |
_aImpact of Histological Factors of Hepatocellular Carcinoma on the Outcome of Liver Transplantation. _h[artículo] |
260 |
_bTransplantation proceedings, _c2016 |
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300 | _a48(6):1968-77. | ||
500 | _aFormato Vancouver: Donat M, Alonso S, Pereira F, Ferrero E, Carrión L, Acin Gándara D et al. Impact of Histological Factors of Hepatocellular Carcinoma on the Outcome of Liver Transplantation. Transplant Proc. 2016 Jul-Aug;48(6):1968-77. | ||
501 | _aPMID: 27569930 | ||
504 | _aContiene 73 referencias | ||
520 | _aBackground: The aim of this study was to identify predictors of overall survival (OS), disease-free survival (DFS), and recurrence in a cohort of 151 patients with hepatocellular carcinoma (HCC) and cirrhosis who were treated by liver transplantation (LT). Patients and methods: A retrospective database of patients undergoing LT for radiologically diagnosed HCC at "12 de Octubre" Hospital, Madrid during 1986-2006 was analyzed. Results: The median follow-up was 67.44 months (SD = 55.7 months). Overall 1-, 3-, 5-, and 10-year survival was 87.5%, 73.7%, 64.1% and 43.4%, respectively. The 5-year OS of patients beyond the Milan criteria was 47.14%, whereas that of patients within the Milan criteria was 70.13% (P = .011). The 5-year OS of patients beyond the Milan criteria and with microvascular invasion (MVI) was 27.27%, whereas that of patients beyond the Milan criteria and without MVI criteria was 57.89% (P = .003). Multivariate analysis of prognostic factors revealed MVI and G3 to be independent and statistically significant factors affecting OS (P < .0001 and P = .045, respectively), DFS (P < .0001 and P = .004, respectively), and recurrence (P = .0002 and P = .028, respectively). Multivariate analysis of prognostic factors also revealed preoperative fine-needle aspiration (FNA) to be an independent negative statistically significant factor affecting recurrence (P = .0022). Multivariate analysis of predictive MVI factors revealed preoperative α-fetoprotein (AFP) levels >200 ng/mL to be an independent positive and statistically significant predictor of MVI (P = .0004). Conclusion: MVI and G3 are independent negative factors affecting OS, DFS, and recurrence. The presence of MVI or AFP levels >200 ng/mL represent a contraindication for LT, as long as the patient is beyond the Milan criteria. | ||
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_9271 _aServicio de Cirugía General y del Aparato Digestivo |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17907.pdf _ySolicitar documento |
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