000			01995na a2200301 4500
999			_c2092 _d2092
003			PC2092
005			20181113113817.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aFerrero Herrero, Eduardo _942 _eCirugía General y del Aparato Digestivo
245	0	0	_aTyrosine phosphorylation modulates the vascular responses of mesenteric arteries from human colorectal tumors. _h[artículo]
260			_bBioMed research international, _c2013
300			_a2013:545983.
500			_aFormato Vancouver: Ferrero E, Mauricio MD, Granado M, García-Villar O, Aldasoro M, Vila JM et al. Tyrosine phosphorylation modulates the vascular responses of mesenteric arteries from human colorectal tumors. Biomed Res Int. 2013;2013:545983.
501			_aPMID: 24324963
520			_aThe aim of this study was to analyze whether tyrosine phosphorylation in tumoral arteries may modulate their vascular response. To do this, mesenteric arteries supplying blood flow to colorectal tumors or to normal intestine were obtained during surgery and prepared for isometric tension recording in an organ bath. Increasing tyrosine phosphorylation with the phosphatase inhibitor, sodium orthovanadate produced arterial contraction which was lower in tumoral than in control arteries, whereas it reduced the contraction to noradrenaline in tumoral but not in control arteries and reduced the relaxation to bradykinin in control but not in tumoral arteries. Protein expression of VEGF-A and of the VEGF receptor FLT1 was similar in control and tumoral arteries, but expression of the VEGF receptor KDR was increased in tumoral compared with control arteries. This suggests that tyrosine phosphorylation may produce inhibition of the contraction in tumoral mesenteric arteries, which may increase blood flow to the tumor when tyrosine phosphorylation is increased by stimulation of VEGF receptors.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842070/ _yAcceso libre
942			_n0 _2ddc _cART