| 000 | 02185na a2200241 4500 | ||
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| 999 |
_c2516 _d2516 |
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| 003 | PC2516 | ||
| 005 | 20210625062757.0 | ||
| 008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_aLeza, Juan Carlos _91995 _eInstituto de Investigación i+12 |
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| 100 |
_aMacDowell, Karina S. _92610 _eInstituto de Investigación i+12 |
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| 245 | 0 | 0 |
_aInflammatory activation and cholinergic anti-inflammatory system in eating disorders. _h[artículo] |
| 260 |
_bBrain Behavior and Immunity, _c2013 |
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| 300 | _a32:33–9. | ||
| 500 | _aFormato Vancouver: MacDowell KS, Díaz-Marsá M, Güemes I, Rodríguez A, Leza JC, Carrasco JL. Inflammatory activation and cholinergic anti-inflammatory system in eating disorders. Brain Behav Immun. 2013;32:33–39. | ||
| 501 | _aPMID: 23624297 | ||
| 504 | _aContiene 48 referencias | ||
| 520 | _aDysfunctional serotoninergic regulation and hypothalamic-pituitary-adrenal (HPA) axis overreactivity have been consistently reported in research studies with eating disorders (ED). In addition, the links between stress response, serotonin function, HPA axis and inflammatory mechanisms in ED have also been suggested in a number of studies. In our study, inflammatory parameters in white blood cells were investigated in 26 female patients with ED and 25 healthy control subjects matched for sex, age and ethnicity. Patients were free of medication for at least two weeks at the time of the study. Results showed a significant increase in plasma levels of the proinflammatory cytokine IL-1 beta and the protein expression of cyclooxygenase 2 (COX2) in peripheral mononuclear blood cells (PMBCs) in ED patients compared with controls. As well as a significant increase of the oxidative-nitrosative marker TBARS (Thiobarbituric Acid Reactive Substances) in plasma. These findings were associated with increased expression of the alpha7 subunit of the nicotinic receptor (alpha 7nAChR) in PMBC in ED patients independent of plasma cotinine levels. These results suggest that a pro-inflammatory and oxidant phenotype might be present in ED patients. Further research on cellular inflammatory and anti-inflammatory pathways might be oriented to investigate differences between ED subtypes and to search for new potential targets for pharmacological treatment. | ||
| 710 |
_9625 _aInstituto de Investigación imas12 |
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| 856 |
_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/2/pc2516.pdf _ySolicitar documento |
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_n0 _2ddc _cART |
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