000			01999na a2200229 4500
003			H12O
005			20210625062759.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91013 _aMorán Jiménez, María Josefa _eInstituto de Investigación i+12
245	0	0	_aMitochondrial biogenesis related endurance genotype score and sports performance in athletes _h[artículo]
260			_bMitochondrion, _c2011
300			_a11(1):64-69.
500			_aFormato Vancouver: Eynon N, Ruiz JR, Meckel Y, Morán M, Lucia A. Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion. 2011 ;11(1):64-9.
501			_aPMID:20647061
504			_aContiene 32 referencias
520			_aWe determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 +/- 17.1) compared with controls (30.6 +/- 12.4) or power athletes (29.0 +/- 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3043.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c3043 _d3043