000			01397na a2200229 4500
003			H12O
005			20180417112255.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aspa
100			_91686 _aMenéndez Rubio, José María _eCirugía General y del Aparato Digestivo
245	0	0	_aEpigenética y cáncer colorrectal. _h[artículo]
260			_bCirugía Española, _c2012
300			_a90(5):277-83.
500			_aFormato Vancouver: Menéndez P, Villarejo P, Padilla D, Menéndez JM, Rodríguez Montes JA. Epigenética y cáncer colorrectal.Cir Esp. 2012 May;90(5):277-83.
501			_aPMID: 22425513
504			_aContiene 46 referencias
520			_aThe epigenetic and physiological mechanisms that alter the structure of chromatin include the methylation of DNA, changes in the histones, and changes in RNA. A literature review has been carried out using PubMed on the evidence published on the association between epigenetics and colorectal cancer. The scientific literature shows that epigenetic changes, such as genetic modifications may be very significant in the origin of neoplastic disease, contributing both to the development and progression of the disease.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3437.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c3437 _d3437