| 000 | 02207na a2200229 4500 | ||
|---|---|---|---|
| 003 | PC3909 | ||
| 005 | 20210625062800.0 | ||
| 008 | 130622s2012 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_aCuezva, J.M. _91891 _eInstituto de Investigación i+12 |
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| 245 | 0 | 0 |
_aAMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells. _h[artículo] |
| 260 |
_bBiochemical Journal, _c2012 |
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| 300 | _a444(2):249-59. | ||
| 500 | _aFormato Vancouver: Martínez-Reyes I, Sánchez-Aragó M, Cuezva JM. AMPK and GCN2-ATF4 signal the repression of mitochondria in colon cancer cells. Biochem J. 2012 Jun 1;444(2):249-59. | ||
| 501 | _aPMID: 22435535 | ||
| 504 | _aContiene 49 referencias | ||
| 520 | _aReprogramming of energetic metabolism is a phenotypic trait of cancer in which mitochondrial dysfunction represents a key event in tumour progression. In the present study, we show that the acquisition of the tumour-promoting phenotype in colon cancer HCT116 cells treated with oligomycin to inhibit ATP synthase is exerted by repression of the synthesis of nuclear-encoded mitochondrial proteins in a process that is regulated at the level of translation. Remarkably, the synthesis of glycolytic proteins is not affected in this situation. Changes in translational control of mitochondrial proteins are signalled by the activation of AMPK (AMP-activated protein kinase) and the GCN2 (general control non-derepressible 2) kinase, leading also to the activation of autophagy. Changes in the bioenergetic function of mitochondria are mimicked by the activation of AMPK and the silencing of ATF4 (activating transcription factor 4). These findings emphasize the relevance of translational control for normal mitochondrial function and for the progression of cancer. Moreover, they demonstrate that glycolysis and oxidative phosphorylation are controlled at different levels of gene expression, offering the cell a mechanistic safeguard strategy for metabolic adaptation under stressful conditions. | ||
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_9625 _aInstituto de Investigación imas12 |
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| 856 |
_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/3/pc3909.pdf _ySolicitar documento |
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_n0 _2ddc _cART |
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_c3909 _d3909 |
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