000			02608na a2200229 4500
003			H12O
005			20210706062654.0
008			130622s2012 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91250 _aDelgado Jiménez, Juan Francisco _eCardiología
245	0	0	_aInfluence of Steroid Dosage, Withdrawal, and Reinstatement on Survival After Heart Transplantation: Results From the RESTCO Study. _h[artículo]
260			_bTransplantation Proceedings, _c2012
300			_a44(9):2679-81.
500			_aFormato Vancouver: Delgado Jiménez J, Almenar Bonet L, Paniagua Martín MJ, Gómez Bueno M, Yáñez JF, Arizón Del Prado JM, et al. Influence of steroid dosage, withdrawal, and reinstatement on survival after heart transplantation: results from the RESTCO study. Transplant Proc. 2012 Nov;44(9):2679-81.
501			_aPMID: 23146492
504			_aContiene 4 referencias
520			_aLittle information is available regarding the consequences of steroid withdrawal following heart transplantation (HT) in Spain. METHODS: We analyzed the records of 1068 patients (81.6% men) who underwent HT between 2000 and 2005 in 13 Spanish centers who were aged ≥ 18 years and who survived at least 1 year. Death rates and Kaplan-Meier survival curves for 1 to 5 years post-HT were compared among four groups: groups A and B, patients on steroids throughout the first 5 years post-HT at dosages of ≤ 5 mg/d between 1-year and 5-year follow-up (group A; n = 148), or >5 mg/d for some part of this period (group B; n = 578). Groups C and D were patients from whom steroids were at some point withdrawn including group D (n = 73) with and group C (n = 269) without subsequent reintroduction into the maintenance regimen. RESULTS: Steroids were withdrawn at 1.6 ± 0.9 years post-HT in group C, and 1.7 ± 1.2 years post-HT in group D. The death rate between 1- and 5-year follow-up (deaths per 1000 person-years) was 44.3% (95% confidence interval 26.2-62.5) in group A, 42.6% (33.7-51.4) in group B, 30.5% (19.6-41.4) in group C, and 47.8% (21.8-73.7) in group D. There was no significant difference among them or among Kaplan-Meier survival curves of the four groups (P = .34 in both cases). Comparison of combined groups C + D with groups A + B showed no evidence of a greater mortality among combined groups C + D. CONCLUSIONS: The late withdrawal of steroids following HT was not associated with increased mortality.
710			_9119 _aServicio de Cardiología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/4/pc4211.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c4211 _d4211