000			01423na a2200289 4500
999			_c5235 _d5235
003			PC5235
005			20210625062802.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aRuano Domínguez, Yolanda _92579 _eInstituto de Investigación i+12
100			_aHernández Laín, Aurelio _9624 _e Anatomía Patológica
245	0	0	_aCodeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumor.s _h[artículo]
260			_bActa neuropathologica, _c2013
300			_a126(2):277-89.
500			_aFormato Vancouver: Mur P, Mollejo M, Ruano Y, de Lope ÁR, Fiaño C, García JF et al. Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors. Acta Neuropathol. 2013 Aug;126(2):277-89.
501			_aPMID: 23689617
504			_aContiene 59 referencias
520			_aOligodendroglial tumors (OTs) are primary brain tumors that show variable clinical and biological behavior. The 1p/19q codeletion is frequent in these tumors, indicating a better prognosis and/or treatment response. Recently, the prognostically favorable CpG island methylator phenotype (CIMP) in gliomas (G-CIMP+) was associated with mutations in the isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 (IDH) genes, as opposed to G-CIMP- tumors, highlighting the relevance of epigenetic mechanisms.
710			_9330 _aServicio de Anatomía Patológica
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc5235.pdf _ySolicitar documento
942			_n0 _2ddc _cART