000			01528na a2200193 4500
999			_c5296 _d5296
003			PC5296
005			20181203134251.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aspa
100			_aRuilope Urioste, Luis Miguel _9539 _eNefrología
100			_aSegura de la Morena, Julián _91486 _eNefrología
245	0	0	_aContribucion del riñón en la homeostasis de la glucosa. _h[artículo]
260			_bMedicina clínica, _c2013
300			_a141 Suppl 2:26-30.
500			_aFormato Vancouver: Segura J, Ruilope LM. Contribucion del riñón en la homeostasis de la glucosa. Med Clin (Barc). 2013 Sep;141 Suppl 2:26-30.
501			_aPMID: 24444521
504			_aContiene 26 referencias
520			_aThe kidney is involved in glucose homeostasis through three major mechanisms: renal gluconeogenesis, renal glucose consumption, and glucose reabsorption in the proximal tubule. Glucose reabsorption is one of the most important physiological functions of the kidney, allowing full recovery of filtered glucose, elimination of glucose from the urine, and prevention of calorie loss. Approximately 90% of the glucose is reabsorbed in the S1 segment of the proximal tubule, where glucose transporter-2 (GLUT2) and sodium-glucose transporter-2 (SGLT2) are located, while the remaining 10% is reabsorbed in the S3 segment by SGLT1 and GLUT1 transporters. In patients with hyperglycemia, the kidney continues to reabsorb glucose, thus maintaining hyperglycemia. Most of the renal glucose reabsorption is mediated by SGLT2. Several experimental and clinical studies suggest that pharmacological blockade of this transporter might be beneficial in the management of hyperglycemia in patients with type 2 diabetes.
710			_986 _aServicio de Nefrología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc5296.pdf _ySolicitar documento
942			_n0 _2ddc _cART