000			02658na a2200313 4500
003			PC69
005			20180417114626.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_a _cH12O
041			_aeng
100			_9560 _aAbradelo de Usera, Manuel _eCirugía General y Aparato Digestivo
100			_aGómez Sanz, Ramón _91065 _eCirugía General y del Aparato Digestivo
100			_9358 _aJiménez Romero, Carlos _eCirugía General y del Aparato Digestivo
100			_9558 _aLoinaz Segurola, Carmelo _eCirugía General y del Aparato Digestivo
100			_aMeneu Díaz, Juan Carlos _91087 _eCirugía General y del Aparato Digestivo
100			_91079 _aMoreno Elola-Olaso, Almudena _eCirugía General y del Aparato Digestivo
100			_9510 _aMoreno González, Enrique _eCirugía General y del Aparato Digestivo
245	0	4	_aThe influence of immunosuppression switching in liver function in adult hepatic transplantation _h[artículo]
260			_bHepatogastroenterology, _c2011
300			_a58(106):532-535.
337			_aJOUR
500			_aFormato Vancouver: Marín Gómez LM, Loinaz Segurota C, Moreno González E, Moreno Elola-Olaso A, González-Pinto Arrillaga I, Meneu Díaz JC, et al. The influence of immunosuppression switching in liver function in adult hepatic transplantation. Hepatogastroenterology. 2011;58(106):532-5.
501			_aPMID: 21661426
504			_aContiene 10 referencias
520			_aWe evaluate the 5-year results of a single-centre prospective randomized trial that compared cyclosporine microemulsion (CyA-me) in triple therapy (plus steroids and azathioprine) and Tacrolimus (Tac) in double therapy (plus steroids) for primary immunosuppression. One hundred adult patients undergoing liver transplantation were randomized to receive Tac (n=51) or CyA-me (n=49). Ten patients in group A, and thirty-one patients in group B had their main immunosuppressive agent switched. The switch was much more frequent from CyA-me to Tac (n=31; 62.3%), mainly because of lack of efficacy (n=12; 38.7%). Six of 10 patients were shifted from Tac to CyA-me for side effects. The clinical course of the majority of patients converted from CyA-me to Tac improved clearly after conversion. Donor age and acute rejection (number, severity and rejection free days) had a significative association with lack of efficacy in group B. In these series, the conversion to Tac from CyA-me could be accomplished safely, with an excellent long-term outcome.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc69.pdf _ySolicitar documento
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999			_c69 _d69