000 | 02165na a2200313 4500 | ||
---|---|---|---|
999 |
_c8070 _d8070 |
||
003 | PC8070 | ||
005 | 20181107143116.0 | ||
008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_aPraga Terente, Manuel _91488 _eNefrología |
||
245 | 0 | 0 |
_aEffect of Dual Blockade of the Renin-Angiotensin System on the Progression of Type 2 Diabetic Nephropathy: A Randomized Trial. _h[artículo] |
260 |
_bAmerican Journal of Kidney Diseases, _c2013 |
||
300 | _a61(2):211-8. | ||
500 | _aFormato Vancouver: Fernández Juárez G, Luño J, Barrio V, de Vinuesa SG, Praga M, Goicoechea M et al. PRONEDI Study Group. Effect of dual blockade of the renin-angiotensin system on the progression of type 2 diabetic nephropathy: a randomized trial. Am J Kidney Dis. 2013 Feb;61(2):211-8. | ||
501 | _aPMID: 22939518 | ||
504 | _aContiene 28 referencias | ||
520 | _aBackground: Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers has been shown to lessen the rate of decrease in glomerular filtration rate in patients with diabetic nephropathy. Study Design: A multicenter open-label randomized controlled trial to compare the efficacy of combining the angiotensin-converting enzyme inhibitor lisinopril and the angiotensin II receptor blocker irbesartan with that of each drug in monotherapy (at both high and equipotent doses) in slowing the progression of type 2 diabetic nephropathy. Setting & Population: 133 patients with type 2 diabetic nephropathy (age, 66 +/- 8 years; 76% men) from 17 centers in Spain. Intervention: Patients were randomly assigned (1:1:2) to lisinopril (n = 35), irbesartan (n = 28), or the combination of both (n = 70). Outcomes: The primary composite outcome was a >50% increase in baseline serum creatinine level, end-stage renal disease, or death. Results: Baseline values for mean estimated glomerular filtration rate and blood pressure were 49 +/- 21 mL/min/1.73 m(2) and 153 +/- 19/81 +/- | ||
710 |
_986 _aServicio de Nefrología |
||
856 |
_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/8/pc8070.pdf _ySolicitar documento |
||
942 |
_n0 _2ddc _cART |